Results 91 to 100 of about 14,574,739 (296)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Care Management Processes Important for High-Quality Diabetes Care. [PDF]

Diabetes Care, 2023
Peterson KA, Carlin CS, Solberg LI, Normington J, Lock EF.   +4 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Possibilities of Using a Multispectral Camera to Assess the Effects of Biostimulant Application in Soybean Cultivation

Sensors
Soybean cultivation plays a crucial role in the global food system, providing raw materials for both the food and feed industries. To enhance cultivation efficiency, plant biostimulants are used to improve metabolism and stimulate growth. A key aspect of
Paweł Karpiński, Sławomir Kocira
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Exploration of pain assessment and management processes in oncology outpatient services with healthcare professionals: a qualitative study. [PDF]

BMJ Open, 2023
Robinson OC, Pini S, Flemming K, Campling N, Fallon M, Richards SH, Mayland CR, Boland E, Swinson D, Hurlow A, Hartup S, Mulvey MR.   +11 more
europepmc   +1 more source

Ensuring theEfficiency of Integration Processes in the International Corporate Sector on the Basis of Strategic Management [PDF]

, 2019
The article raises an important scientific point of increasing the efficiency of integration processes of international corporations based on the concepts of strategic management.
Volodymyr Makedon, Vyacheslav,, Makedon, Volodymyr, Tuzhylkina, Oksana, Stepanova, Larysa, Kostyshyna, Tetyana, Tuzhylkina, Oksana,, Filippov, Vyacheslav   +6 more
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Demand management processes to improve access to cognitive-behavioral therapies for anxiety disorders: a grounded theory study. [PDF]

Front Health Serv, 2023
Carrier JD, Gallagher F, Vanasse A, Roberge P.   +3 more
europepmc   +1 more source

Integrating social customer relationship management into customer relationship management processes in academic library [PDF]

, 2014
Social Customer Relationship Management (SCRM) is a novel concept that unites social media technology with customer relationship management. It is essential that libraries in academic environments and their members require some specific means to ...
Alilou, Farima
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