Results 31 to 40 of about 9,114,449 (315)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Assessment of options for the location of railway infrastructure facilities

Discover Applied Sciences
This article discusses a methodology for assessing optimal cargo facility placement, focusing specifically on evaluating regional attractiveness in Uzbekistan through an integrated attractiveness index.
Gushan Ibragimova, Ziyoda Mukhamedova, Sakijan Khudayberganov, Shuhrat Buriyev, Shokhrukh Kayumov, Alfiya Bashirova, Muslima Akhmedova, Mafratkhon Tokhtakhodjaeva   +7 more
doaj   +1 more source

REPORT MANAGEMENT SYSTEM OF EARLY WARNING ALERT AND RESPONSE SYSTEM PROGRAM EVALUATION, TANAH BUMBU DISTRICT

Jurnal Berkala Epidemiologi, 2022
Background: The threat of outbreaks of infectious diseases is getting significant attention worldwide, and WHO requires all countries to increase early awareness and respond quickly.
Dicky Andiarsa, Deni Fakhrizal, Syarif Hidayat, Gusti Meliyanie, Harninda Kusumaningtyas, Yuniarti Suryatinah   +5 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

REORGANIZATION OF THE PARTY-SOVIET APPARATUS IN THE BSSR (1962–1964)

Вестник Брянского государственного университета, 2022
The article deals with the issues of reorganization of the party and Soviet apparatus of power and management in the BSSR on the basis of the production principle.
Elizarov S.A.
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

VARIANTS AND ACTIVITY PHASES OF MANAGEMENT SYSTEM OF ENTERPRISES PRODUCT POLICY

Статистика и экономика, 2016
The purpose of the article is to study the peculiarities of development and the stages of activity of management system of product policy of enterprise.
Denis I. Lyndin
doaj   +1 more source

Mathematical Model of Economical Assessment of Investments in Information Provision for the Management System of a Modern Company [PDF]

SHS Web of Conferences, 2019
Information provision for a company’s management system not only provides data for evaluating day-to-day operations but also is an efficient tool for improving the reliability of the entire management system. For purposes of efficiently managing projects
Korablev A.V., Petrushova M.V., Pogorelova E.V., Abrosimov A.G.   +3 more
doaj   +1 more source

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior, Edmara Bazoni Soares Maia, Soad Fuentes‐Alabí, Courtney E. Sullivan, Monnie Abraham, Mauricio Maza, Liliana Vásquez Ponce, Regina Aparecida Garcia Lima   +7 more
wiley   +1 more source