Results 41 to 50 of about 6,516,881 (303)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

CONFIGURING THE STREET TRAM THROUGH THE AIMSUN SOFTWARE GRAPHICAL ELEMENTS

Journal of Industrial Design and Engineering Graphics, 2019
The transportation system is a complex, alive and dynamic mechanism. Taking into account all of the problems of a public transport the difficulty is to make a virtual network that can be improved and organized from the point of view of a systemic ...
Alexandru OPRICA, Alexandru DIMA, Dragos TUTUNEA, Lucian MATEI, Ilie DUMITRU   +4 more
doaj   +2 more sources

Erosão hídrica pós-plantio em florestas de eucalipto na região centro-leste de Minas Gerais Water erosion in post-planting eucalyptus forests at center-east region of Minas Gerais State, Brazil

Pesquisa Agropecuária Brasileira, 2006
O objetivo deste trabalho foi avaliar as perdas de solo e água por erosão hídrica, em parcelas-padrão sob chuva natural, no período pós-plantio, em diferentes sistemas de manejo de florestas de eucalipto. O experimento foi instalado em Latossolo Vermelho-
Lislane Sousa Pires, Marx Leandro Naves Silva, Nilton Curi, Fernando Palha Leite, Liziane de Figueiredo Brito   +4 more
doaj   +1 more source

Firm Heterogeneities, Multi-Dimensional Proximities, and Systematic Dynamics of M&A Partnering: Evidences from Transitional China

Systems, 2022
Corporate investment strategies and decision-making processes are crucial for understanding the operation and evolution of socioeconomic systems. Mergers and acquisitions (M&As) have been the main mode of corporate investment, growth, and upgrading ...
Jiawei Wu
doaj   +1 more source

Evaluating cost taxonomies for information systems management [PDF]

, 2006
The consideration of costs, benefits and risks underpin many Information System (IS) evaluation decisions. Yet, vendors and project-champions alike tend to identify and focus much of their effort on the benefits achievable from the adoption of new ...
Ahmad Ghoneim, Anandarajan, Ballantine, Ballantine, David, Earl, Heo, Hirschheim, Hochstrasser, Irani, Irani, Irani, Irani, Irani, Kaplan, Legris, Milis, Peter E.D. Love, Powell, Primose, Remenyi, Renkema, Ryan, Sillince, Wheatley, Zahir Irani   +25 more
core   +1 more source

Acrylamide-Formation Potential of Cereals: What Role Does the Agronomic Management System Play?

Agronomy, 2019
As bakery products contribute considerably to the daily intake of the carcinogen acting substance acrylamide (AA), the aim of this study was to evaluate the impact of the management system (conventional vs. organic farming) on AA precursor levels of free
Falko Stockmann, Ernst Albrecht Weber, Benjamin Mast, Pat Schreiter, Nikolaus Merkt, Wilhelm Claupein, Simone Graeff-Hönninger   +6 more
doaj   +1 more source

Handbook of Emergency Management For State-Level Transportation Agencies, MTI Report 09-10 [PDF]

, 2010
The Department of Homeland Security has mandated specific systems and techniques for the management of emergencies in the United States, including the Incident Command System, the National Incident Management System, Emergency Operations Plans, Emergency
Edwards, Frances L., Goodrich, Daniel C.
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Estimativa da resistência mecânica à penetração de um latossolo vermelho sob cultura perene no norte do estado do Paraná Estimating penetration resistance of an oxisol under perennial crop in northern Paraná state

Revista Brasileira de Ciência do Solo, 2008
Uma das propriedades físicas importantes para o manejo e estudo da qualidade física dos solos é sua resistência à penetração, uma vez que esta propriedade se apresenta relacionada a diversos atributos do solo indicadores do grau de compactação.
Adriana Aparecida Ribon, João Tavares Filho   +1 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source