Results 121 to 130 of about 734,979 (333)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Impact of social auditing on well-being at work in CSR labeled companies in Morocco

Qubahan Academic Journal
In a context where stakeholder expectations for corporate social responsibility (CSR) are rising, the role of social auditing in promoting employee well-being remains underexplored, particularly in developing countries.
Sara Nait Slimane , Nacer Mahouat, Sophia Vandapuye   +2 more
doaj   +1 more source

An Exploration of Customer-Defined Perception of Market Orientation:Antecedents and Consequences [PDF]

, 2011
As universities worldwide are being required to be more responsive to the needs of their customers, the literature has focused on identifying exactly who is the customer in the higher education industry.
Akinyele, S.T.
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

"Principles of Effective Management According to Quran and Sunnah "

الإيضاح, 2016
The aim of this conceptual paper is throw light on Islamic principles for effective human resource management. A qualitative approach was applied. The extensive review of existing literature shows that Islamic principles of HRM gives due importance to ...
Zafar Saleem., Muhammad Tahir Malik, Dr Sajid Rahman Khattak   +2 more
doaj  

The effect of managers’ optimism on competitive strategy and final cost models [PDF]

, 2019
Currently, competition in the global economy is the most complex issue that gives organizations a lot of opportunities and threats. Therefore, the manager of the organization should be able to enhance the organization's performance in this competitive ...
Farajpouri Haghigh, H, Yazdifar, H
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Opportunities Arising from Change Management in Business Organizations

Ekonomski Vjesnik, 2011
Change management is a systematic process of applying different knowledge, procedures and means required for the change to reflect on people that will be influenced by it.
Anita Kuleš
doaj  

PATTERNS OF BEHAVIOUR IN THE MANAGER-EMPLOYEE RELATIONSHIP – THE RESULTS OF EMPIRICAL RESEARCH IN POLISH BUSINESS ORGANIZATIONS

Journal of Positive Management, 2017
Purpose: The purpose of the article is to identify patterns of organizational behaviour for the manager-employee relationship and to identify differences in this respect depending on the position of the individual in the organizational structure against the background of the official business relationship on the basis of the empirical research in ...
openaire   +2 more sources