Results 91 to 100 of about 327,740 (280)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

ÖRGÜTSEL ADALETİN YÖNETİCİ-ÇALIŞAN İLİŞKİLERİ ÜZERİNE ETKİSİ: FARKLI SEKTÖR ÇALIŞANLARINA YÖNELİK BİR ARAŞTIRMA

open access: yesSosyal Ekonomik Araştırmalar Dergisi, 2009
Bu çalışmanın temel amacı, örgütsel adaletin, yönetici-çalışan ilişkileri üzerine olan etkisini tespit etmektir. Çalışmanın amaç ve doğrultusunda geliştirilen hipotezleri test etmek amacıyla elektrik ve elektronik yedek parça sanayinde, yapı malzemeleri ...
Yavuz DEMİREL
doaj   +4 more sources

Designing a security-oriented leadership model of Mazandaran University of Medical Sciences [PDF]

open access: yesمدیریت و چشم انداز آموزش
The goal is designing a security-oriented leadership model of Mazandaran University of Medical Sciences, which is a fundamental study in terms of research orientation, and a mixed exploratory one in terms of data analysis method.
Saeid Miladigorji   +2 more
doaj   +1 more source

Investing in Entry-Level Talent [PDF]

open access: yes, 2017
Even in today's competitive economic environment, there is much that companies can do to reduce entry-level turnover costs, increase employee engagement and retention, and create a talent pipeline for the future. Many companies pursue basic strategies to
Fay Hanleybrown, Kimbery Gilsdorf
core  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Work Organisation and Innovation - Case Study: Company X, Slovenia [PDF]

open access: yes, 2013
[Excerpt] Company X is one of the largest and most successful commercial grocery retailing chains in south-eastern Europe (Euromonitor, 2011). It was established over 60 years ago in Ljubljana, Slovenia.
Darija, Aleksić   +2 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Issues in Managerial Compensation Research [PDF]

open access: yes, 1995
[Excerpt] Compensation is at the core of any employment exchange (Milkovich & Newman, 1993; Simon, 1951). It is probably the most basic reason people agree to become employees and it serves as a defining characteristic of any employment relationship ...
Bloom, Matthew C.   +1 more
core   +1 more source

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