Results 31 to 40 of about 308 (134)

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

How wildlife respond to tropical cyclones: short‐term tactics and long‐term impacts

Biological Reviews, EarlyView.
ABSTRACT From butterflies to lizards and from sharks to seabirds, wildlife exhibit tactics to survive the impacts of tropical cyclones, also known as hurricanes, cyclones, or typhoons depending on where they occur. Some species seek refuge during the storm by moving, some remain in place and ride it out, and others move longer distances, avoiding the ...
Erin L. Koen, Mohamed Khalil Meliane, Zachery B. Holmes, Karl E. Miller, William J. Barichivich, Emilie Dedeban, Alex Furst, Miranda Imeri, Peyton E. Niebanck, Samantha Nunn, Kailee Pearson, Nicole Rita, Brier Ryver, Dakotah Shaffer, Susan C. Walls, E. Hance Ellington   +15 more
wiley   +1 more source

Development and Improvement of Habitat Suitability Criteria for Instream Habitat Assessments Conducted in Support of Environmental Flows in Florida

River Research and Applications, EarlyView.
ABSTRACT Florida's regulatory framework requires the establishment of minimum flows to protect aquatic ecosystems and water resources from significant harm. One of the primary methods used to evaluate significant harm is assessment of instream habitat, which relies on Habitat Suitability Criteria (HSC) curves that relate flow regimes and habitat ...
Eric J. Nagid, Kym Rouse Holzwart
wiley   +1 more source

Identification of alimentary components of Antillean manatee diet in the Northeast of Brazil [PDF]

Biotemas, 2008
The manatees are considered to be opportunist herbivors, consuming a great amount of alimentary items. The aim of the present study was to identify the alimentary components of the diet of Antillean manatees in free life in the northeastern region of ...
Daiane Garcia Anzolin, George Emmanuel Cavalcanti de Miranda, Patrícia Guimarães Araújo, João Carlos Gomes Borges   +3 more
doaj  

Microplastics in large marine herbivores: Florida manatees (Trichechus manatus latirostris) in Tampa Bay

Frontiers in Ecology and Evolution, 2023
Although there is growing concern about ingestion of microplastics by marine organisms, little research has been conducted on marine herbivores. This is the first study to document microplastic ingestion within the family Sirenia.
Shannon Gowans, Amy N. S. Siuda
doaj   +1 more source

First Non‐Invasive Monitoring of Fecal Steroids in Greater Caribbean Manatees (Trichechus manatus manatus)

Zoo Biology, EarlyView.
This study established the first fecal hormonal reference values (P4/E2) for the Greater Caribbean manatee. Using non‐invasive ELISA, the authors found no significant differences between mature and immature females, highlighting that long‐term monitoring and ultrasounds are essential to fully understand their complex reproductive cycles.
Vanessa Bermúdez‐Cardona, Roberto Sánchez‐Okrucky, José A. Sandoval‐Zárate, Nataly Castelblanco‐Martínez   +3 more
wiley   +1 more source

The Antillean Manatee in the North of Maracaibo Lake (Venezuela): Distribution, and Conservation Issues

Acta Biológica Colombiana
In Venezuela, Antillean manatees (Trichechus manatus manatus) have declined mainly due to habitat loss and degradation, but other threats to the species persist.
Adda Gabriela Manzanilla-Fuentes, Amanda Pérez de Villasmil, Nataly Castelblanco-Martínez, Jim Hernández, Andrés Eloy Seijas, Rafael Moreno-Arias   +5 more
doaj   +1 more source

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

Sensory Biology of the Franciscana (Pontoporia blainvillei, Pontoporiidae, Cetartiodactyla): Ontogenetic Modifications of Vibrissae and Vibrissal Crypts

Integrative Zoology, EarlyView.
The transition of cetaceans from a terrestrial to an aquatic environment involved a crucial sensory adaptation to environments with limited visibility. Vibrissae, important mechanoreceptors, undergo an ontogenetic transformation in odontocetes. This research describes the histomorphology of vibrissae and crypts at different developmental stages ...
Cecilia Mariana Krmpotic, Cleopatra Mara Loza, Alejo Carlos Scarano, Pedro Fernando Andrés‐Laube, Francisco Acuña, Juan Pablo Loureiro, Carolina Natalia Zanuzzi, Nicolás Nahuel Castro, María Teresa Pombo, Lorenzo von Fersen, Claudio Gustavo Barbeito   +10 more
wiley   +1 more source

Corneal transplantation: Restoring sight to the blind

Acta Ophthalmologica, EarlyView.
Abstract Corneal blindness is one of the leading causes of vision loss worldwide. Transplantation of the cornea can restore vision and make blind patients see again. Corneal transplant surgery has undergone major evolution in recent decades with the advent of minimally invasive lamellar surgical approaches such as DMEK and DALK.
Claus Cursiefen
wiley   +1 more source