Results 41 to 50 of about 468,586 (280)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Face mask uptake in the absence of mandates during the COVID-19 pandemic: a qualitative interview study with Swiss residents

BMC Public Health, 2021
Background In the COVID-19 pandemic, Switzerland introduced broad nationwide face mask mandates only by October 2020, later than other Western European countries.
Bettina Maria Zimmermann, Johanna Eichinger, Franziska Schönweitz, Alena Buyx   +3 more
doaj   +1 more source

Private-Sector Mandates in Federal Legislation [PDF]

, 2013
Federal laws and regulations sometimes require non-federal entities to expend their resources to carry out national policies. The Unfunded Mandates Reform Act of 1995 (UMRA), enacted as Public Law 104-4, defines many of those requirements as federal ...
Congressional Budget Office
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

CONTEMPORARY U.S. FEDERALISM: COERCIVE CHANGE WITH COOPERATIVE CONTINUITY [PDF]

Revista d'Estudis Autonòmics i Federals, 2008
Contemporary U.S. federalism is a complex mixture of coercive, cooperative,and dual elements. Constitutionally and politically, the federal system hasbecome coercive because there has been a vast expansion of federal-governmentpower over the states since
John Kincaid
doaj  

State-level prescription drug monitoring program mandates and adolescent injection drug use in the United States, 1995-2017: A difference-in-differences analysis.

PLoS Medicine, 2020
BackgroundPrescription opioid misuse is an ongoing crisis and a risk factor for injection drug use (IDU). Few studies have evaluated strategies for preventing opioid or IDU initiation among adolescents.
Joel J Earlywine, Scott E Hadland, Julia Raifman   +2 more
doaj   +1 more source

Protection motivation unmasked: Applying protection motivation theory to skepticism toward COVID-19 mask and vaccine mandates

AIMS Public Health, 2022
Variants of COVID-19 have sparked controversy regarding mask and/or vaccine mandates in some sectors of the country. Many people hold polarized opinions about such mandates, and it is uncertain what predicts attitudes towards these protective behavior ...
Robin M. Kowalski, Kenzie Hurley, Nicholas Deas , Sophie Finnell, Kelly Evans, Chelsea Robbins, Andrew Cook, Emily Radovic, Hailey Carroll, Lyndsey Brewer, Gabriela Mochizuki   +10 more
doaj   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Problems of substituting vacant deputy’s mandates due to early termination of powers of a deputy elected within a list of candidates

Известия высших учебных заведений. Поволжский регион: Общественные науки, 2022
Background. The distribution of deputy mandates after the end of the elections is one of the most controversial issues in legal science. The use of various methods of mandate distribution directly determines the implementation of electoral rights.
M.Yu. Emelin, B.V. Nikolaev
doaj   +1 more source

Are We #StayingHome to Flatten the Curve? [PDF]

, 2020
The recent spread of COVID-19 across the U.S. led to concerted efforts by states to ``flatten the curve" through the adoption of stay-at-home mandates that encourage individuals to reduce travel and maintain social distance.
Sears, James, Villas-Boas, Miguel, Villas-Boas, Sofia B, Villas-Boas, Vasco   +3 more
core