Results 91 to 100 of about 361,055 (307)
The Provision of Visitable Housing in Australia: Down to the Detail
Social Inclusion, 2015 In response to the ratification of the United Nations Convention of the Rights of People with Disabilities (CRPD), Australian housing industry leaders, supported by the Australian Government, committed to transform their practices voluntarily through the
Margaret Ward, Jill Franz
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Mandatory pre-abortion counseling is a barrier to accessing safe abortion services
The Pan African Medical Journal, 2020 Empirical research showcases that pre-abortion counseling scarcely reverses the woman’s decision either to terminate a pregnancy or not. Growing evidence regarding the high levels of decisional certainty among women seeking abortions renders a careful ...
Luchuo Engelbert Bain
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Neuropsychiatric Disease and Treatment, 2018 Gi Moon Noh,1 Sang Min Lee,2 Geon Ho Bahn2 1Department of Psychiatry, Kyung Hee University Hospital, Seoul, Republic of Korea; 2Department of Psychiatry, Kyung Hee University School of Medicine, Seoul, Republic of Korea Purpose: This study examined the
Noh GM, Lee SM, Bahn GH
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Incidencia del nuevo marco normativo de auditoría en el ejercicio de la revisoría fiscal en Colombia
Dictamen Libre, 2016 The globalization of the economy is the pillar that triggered the implementation of accounting standards and assurance of financial information worldwide acceptance in Colombia, who in order to begin the process of convergence, had to amend its ...
Blas Enrique Barreto Mardach +1 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
DEVELOPMENTS IN THE MARKET OF MANDATORY PRIVATE PENSION FUNDS IN ROMANIA [PDF]
Annals of the University of Craiova: Economic Sciences Series, 2016 Starting from 2008, Romania has a pension system that is based on three pillars: re-distributive type pension scheme (Pay As You Go) - Pillar I, mandatory private pension funds - Pillar II and facultative pensions - Pillar III. This system is inspired by
Gheorghe Matei, Constantin Durac
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