Results 141 to 150 of about 2,272,520 (250)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Institutionalizing medical certification of cause of death training: experiences and insights from seven countries. [PDF]

Glob Health Action
Khan RA, Plaza B, Marinho F, Islam N, Uddin M, Gordillo Alfonso NA, Torres Umbarila AL, Ayenew W, Worabu Y, Atraga A, Azeze T, Dergeba S, Haile M, Mio H, Nzioka W, Kariuki D, Mutheu E, Ngoboka G, Tuyishime A, Wadugedara R, Nimdinu M, Somatunga L, Msigwa G, Kumalija C, Magembe G, Nyondo T, Mswia R, Mwanza J, Setel P, Santon R, Bratschi M.   +30 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mandatory Retirement Task Force Final Report, April 10, 1990

, 1990
University of Minnesota. Mandatory Retirement Task Force, 1990. (1990). Mandatory Retirement Task Force Final Report, April 10, 1990.
University of Minnesota. Mandatory Retirement Task Force, 1990
core  

Variability and Innovation in Faculty Development Models in Emergency Medicine. [PDF]

AEM Educ Train
Baez J, Promes S, Ellis N, Zandt KL, Noelker J, Paulsen R, Char D, Kass L, Leenellett E, McDonough E, Santen SA.   +10 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

For Whom the 'Retirement' Bell Tolls: Inter-temporal Comparisons Using the 1994 and 2002 Canadian General Social Survey [PDF]

Data from the 2002 and 1994 General Social Survey are used to analyze the determinants of retiring due to mandatory retirement and the expected age of retirement in Canada.
admin, clsrn, Gunderson, Morley, Gomez, Rafael   +2 more
core  

Misinformation, Freedom of Expression and Mandatory Vaccination. [PDF]

Public Health Ethics
Kraaijeveld SR.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Hybrid Hub-and-Spoke Model: Revolutionizing Split Liver Transplantation Through Normothermic Machine Perfusion and AI-Driven Allocation. [PDF]

Pediatr Transplant
Long TCD, Khoi PM, Talaat Rahma N, Ho DLB, Nguyen QG, Huy NT.   +5 more
europepmc   +1 more source