Results 231 to 240 of about 514,928 (277)
Advanced Science, EarlyView.A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo +10 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies MZF1 as a core regulator of colon cancer via SnoN‐mediated TGF‐β suppression, proposes 10Panx Acetate as a targeted inhibitor, and validates MZF1/SnoN as prognostic markers for aggressive disease. ABSTRACT Colon cancer progression is associated with transcriptional and signaling abnormalities.
Siqi Sheng +9 more
wiley +1 more source
Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants
Advanced Science, EarlyView.Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer +17 more
wiley +1 more source
Vaccination of healthcare workers: is mandatory vaccination needed?
Expert Review of Vaccines, 2019 Introduction: Vaccinations of healthcare workers (HCWs) aim to directly protect them from occupational acquisition of vaccine-preventable diseases (VPDs) and to indirectly protect their patients and the essential healthcare infrastructure.
Venerando Rapisarda +2 more
exaly +4 more sources
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The case for mandatory vaccination
Nature, 2019When immunization rates dip, legislation is often strengthened. But does the evidence stack up? When immunization rates dip, legislation is often strengthened. But does the evidence stack up?
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The legality of mandatory vaccination
Indian Journal of Medical Ethics, 2019Vaccination in India has been carried out for the past 70 years and is seen as a major part of the public health policy of independent India. Its ability to provide for an efficient and cheap form of preventive healthcare makes it the most viable option for a developing state such as India.
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The issue of mandatory vaccination for healthcare workers in Europe
Expert Review of Vaccines, 2014 Mandatory policies have occasionally been implemented, targeting optimal vaccination uptake among healthcare workers (HCWs). Herein, we analyze the existing recommendations in European countries and discuss the feasibility of implementing mandatory ...
Pier Luigi Lopalco +2 more
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Mandatory vaccination: is it ethical?
Practice Nursing, 2021Mandatory – or compulsory – vaccinations are controversial, with some arguing that individuals should have the right to assert their personal decisions without state interference. The recent decision to make COVID-19 vaccination mandatory for frontline NHS workers in England, as well as those working in social care, has thrown the idea into the ...
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Debating the future of mandatory vaccination
BMJ, 2017Mandatory vaccination should be debated before an epidemic or public health emergency to assure that public health law is graduated and proportionate.1 Mandated vaccination of children is not currently warranted in light of the current levels of herd immunity. Important historical lessons on the efficacy of legal mandate flow from …
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Should childhood vaccination be mandatory? No
BMJ, 2012Paul Offit (doi:10.1136/bmj.e2434) believes that mandatory vaccination is needed to protect vulnerable people from infection, but David Salisbury argues that there are more workable ways to ensure high ...
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