Results 31 to 40 of about 14,531 (351)

Comparative analysis of surface modeling in computer-aided design systems

Литьë и металлургия
This study presents a comprehensive analysis of the surface modeling capabilities of two leading contemporary computeraided design (CAD) software packages: KOMPAS-3D and SOLIDWORKS.
A. A. Maiorov
doaj   +1 more source

Research on the impact of mandrels in titanium tubes during tube continuous rolling

Materials Research Express, 2023
Tube continuous rolling (TCR) is a beneficial method for the production of titanium pipes due to its high efficiency and shorter process, with the mandrel playing a crucial role.
Chao Li, Yuanhua Shuang, Jianxun Chen, Yan Zhou, Chen Wang, Chen Chen, Yujun Gou, Bowen Dong   +7 more
doaj   +1 more source

Modified Split Mandrel Method and Equipment to Improve the Fatigue Performance of Structural Components with Fastener Holes

Metals
Fastener holes are among the most common natural stress concentrators in metal structures. The life cycles of various structural elements, such as those in aircraft structures, automobiles, and rail-end bolt joints, are limited by fatigue damage around ...
J. Maximov, G. Duncheva, A. Anchev, V. Dunchev, Petya Daskalova   +4 more
semanticscholar   +1 more source

Evaluation of quality parameters of conical profile compounds in nodes of multi-purpose machines [PDF]

E3S Web of Conferences, 2019
The article presents a study of the mandrel spindle assembly for accuracy, contact stiffness and strength. The study was made on the basis of conical profile connections with an equiaxed contour. Experiments were carried out for multi-purpose machines of
Il’inykh Viktor
doaj   +1 more source

Research and development of broaching methods on mandrel of large-sized pipe forgings

IOP Conference Series: Materials Science and Engineering, 2020
In modern day industry of heavy engineering, parts made from billets comprising large-sized pipe forgings are widely used. The paper presents results of the study of various methods of broaching on mandrel of large-sized pipe forgings and presents the ...
O. Kobelev, S. Albul, N. Kirillova
semanticscholar   +1 more source

Mandrel degradation model of combined fast and slow processes

High Power Laser Science and Engineering, 2021
In this paper, we report the study of degradation for a kind of ideal mandrel material called poly-α-methylstyrene based on theoretical and experimental methods.
Yu Zhu, Zheng Liu, Famin Yu, Qiang Chen, Wei Feng, Zhanwen Zhang, Zhigang G. Wang   +6 more
semanticscholar   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

An Analysis of Angular Indexing Error of a Gear Measuring Machine

Applied Sciences, 2018
In gear measuring machines (GMMs), the tested gear is mounted on a mandrel, which is pivoted at both ends by two centers in a vertical arrangement. The upper center is fixed and the lower center is driven by the spindle of rotation.
Zhi-Feng Lou, Peng-Fei Xue, Yuan-Song Zheng, Kuang-Chao Fan   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source