Results 161 to 170 of about 66,270 (266)

Targeted autonomic testing for radiation‑induced baroreflex failure in head and neck cancer survivors: index case and early program experience. [PDF]

Cardiooncology
Triantafyllou E, Flores IG, Iliescu C, Deswal A, Mouhayar E, Fuller CD, Koutroumpakis E.   +6 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Modified Guide Anchoring "UNICORN" Technique for Valve-in-Valve TAVI: Navigating Hostile Anatomy With Leaflet Laceration. [PDF]

JACC Case Rep
Althobaiti M, Alghadeer S, Alsaileek A, Aljizeeri A, Abdelsalam W, Asiri M, Algazlan S, Alshamardl K, Aljuaid A, Algethami A.   +9 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Advantages of Posterior Harms-Goel C1C3 Fixation over Anterior C2C3 Discectomy and Fusion with Plate and Screws for Highly Unstable Hangman's Fracture: Time to Close the Debate? [PDF]

Spine Surg Relat Res
Beucler N.
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Umbilical vein-ductus venosus angle: a novel ultrasound marker for predicting optimal umbilical venous catheter placement. [PDF]

Eur J Pediatr
Gierek K, Mikołajczak A, Stefańska M, Kusibab-Mytych M, Różańska K, Bokiniec R.   +5 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Open repair after failed endovascular treatment of a visceral arterial aneurysm: The Mattox maneuver. [PDF]

J Vasc Surg Cases Innov Tech
Díaz de Lope-Díaz RG, Antona EM, Rydings MH, Cantalejo-Ferrer MS, López IM.   +4 more
europepmc   +1 more source