Results 81 to 90 of about 66,270 (266)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Ecology and EvolutionSpecies detections often vary depending on the survey methods employed. Some species may go undetected when using only one approach in community‐level inventory and monitoring programs, which has management and conservation implications.
Sasha J. Tetzlaff +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Maneuver Detection via a Confidence Dominance Maneuver Indicator
CoRRAccurate and efficient maneuver detection is critical for ensuring the safety and predictability of spacecraft trajectories. This paper presents a novel maneuver detection approach based on comparing the confidence levels associated with the orbital state estimation and the observation likelihood. First, a confidence-dominance maneuver indicator (CDMI)
Xingyu Zhou +4 more
openaire +2 more sources
Orbital Maneuver using Two-Step Sliding Mode Control [PDF]
Journal of Astronomy and Space Sciences, 1998 The solutions of orbital maneuver problem using the sliding mode control in the presence of the earth gravitational perturbations is obtained. Especially, the optimization of consuming fuel for maneuver is performed.
Jong-Uk Park, Sanuk Lee, Kyu-Hong Choi
doaj
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Are Relieving Maneuvers Useful in Diagnosis of Carpal Tunnel Syndrome?
The Turkish Journal of Gastroenterology, 2008 Objective: Our aim was to assess and compare the diagnostic accuracy of the carpal tunnel syndrome relief maneuver (CTS-RM) and the Flick sign for the diagnosis of carpal tunnel syndrome (CTS) in female patients.
Haydar Gok, Saime Ay, Sehim Kutlay
doaj