Susceptibility to Lenacapavir Among Newly Diagnosed HIV-Positive Patients Followed Up in Mozambique That Presented With Primary Antiretroviral Resistance to Other Classes. [PDF]
ABSTRACT Multidrug‐resistant HIV patients have limited ART options. Lenacapavir (LEN) is a capsid inhibitor that exhibits substantial antiviral activity in patients with therapeutic failure but is also proposed for PrEP. Herein, we assessed LEN susceptibility among ART‐naive HIV patients with drug resistance in Mozambique.
Sebastião CS +15 more
europepmc +2 more sources
Major Causes of Perinatal and Paediatric Mortality in Sub-Saharan Africa and South Asia: Adjustment for Selection Bias in the CHAMPS Network. [PDF]
ABSTRACT Background Studies of child mortality that employ minimally invasive tissue sampling (MITS) produce highly accurate cause of death data; however, selection bias may render these as non‐representative of their underlying populations. Objectives Estimate cause‐specific mortality fractions and rates for the five most frequent causes—underlying ...
Vyas KJ +39 more
europepmc +2 more sources
Understanding accountability in practice: Obligations, scrutiny, and consequences
Summary Motivation Attempting to increase authorities' accountability for their actions has become a mainstay of development practice in recent decades. Yet commentators suggest that these efforts have reached an impasse, in part because of conceptual fuzziness regarding the core ideas of public accountability. Purpose This article explores what we can
Colin Anderson
wiley +1 more source
Citizen action for accountability in challenging contexts: What have we learned?
Summary Motivation While much is known about how citizens mobilize and make claims for accountability in more democratic, stable, and peaceful settings, little is known about how accountability dynamics work in more challenging contexts—those more democratically weak, politically fragile, and affected by legacies of violence and conflict.
John Gaventa +2 more
wiley +1 more source
Abstract Diarrheal disease, still a major cause of childhood illness, is caused by numerous, diverse infectious microorganisms, which are differentially sensitive to environmental conditions. Enteropathogen‐specific impacts of climate remain underexplored.
Josh M. Colston +46 more
wiley +1 more source
Abstract Aim Pneumonia is the leading infectious cause of death among children under five globally. Many pneumonia deaths result from inappropriate treatment due to misdiagnosis of signs and symptoms. This study aims to identify whether health extension workers (HEWs) in Ethiopia, using an automated multimodal device (Masimo Rad‐G), adhere to required ...
Kevin Baker +14 more
wiley +1 more source
Performance of lung ultrasound in the diagnosis of pediatric pneumonia in Mozambique and Pakistan
Abstract Introduction Improved pneumonia diagnostics are needed in low‐resource settings (LRS); lung ultrasound (LUS) is a promising diagnostic technology for pneumonia. The objective was to compare LUS versus chest radiograph (CXR), and among LUS interpreters, to compare expert versus limited training with respect to interrater reliability. Methods We
Amy Sarah Ginsburg +17 more
wiley +1 more source
Bovine brucellosis is among the top five diseases primarily threatening both public health and livestock economy. Available data are limited to central and highland areas of the country leaving documented literature on the disease in cattle to be found hardly in pastoral and agropastoral regions of the country.
Wossene Negash +2 more
wiley +1 more source
Glucose-6-Phosphate Dehydrogenase Deficiency, Chlorproguanil-Dapsone with Artesunate and Post-treatment Haemolysis in African children treated for uncomplicated Malaria [PDF]
Malaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few hours to severe and possibly fatal disease. Chlorproguanil-dapsone-artesunate (CDA)
A Alloueche +45 more
core +3 more sources
Sanitation and Hygiene-Specific Risk Factors for Moderate-to-Severe Diarrhea in Young Children in the Global Enteric Multicenter Study, 2007-2011: Case-Control Study. [PDF]
Background: Diarrheal disease is the second leading cause of disease in children less than 5 y of age. Poor water, sanitation, and hygiene conditions are the primary routes of exposure and infection.
Ahmed, Shahnawaz +21 more
core +1 more source

