Results 201 to 210 of about 629,600 (289)

Oral Citrate Supplementation Mitigates Age‐Associated Pathologic Intervertebral Disc Calcification in LG/J Mice

open access: yesAging Cell, Volume 24, Issue 5, May 2025.
An endochondral differentiation process in the CEPs drives pathologic disc calcification in aging LG/J mice, and NP cell hypertrophic transdifferentiation secondarily contributes. Supplementing drinking water with 80 mM K3Citrate during aging markedly reduced disc calcification, attenuated NP cell transdifferentiation, and mildly improved NP and AF ...
Olivia K. Ottone   +9 more
wiley   +1 more source

The temporal response of bone to unloading [PDF]

open access: yes
Rats were suspended by their tails with the forelimbs bearing the weight load to simulate the weightlessness of space flight. Growth in bone mass ceased by 1 week in the hindlimbs and lumbar vertebrae in growing rats, while growth in the forelimbs and ...
Bikle, D. D.   +2 more
core   +1 more source

Enhancing geriatric trauma mortality prediction: Modifying and assessing the Geriatric Trauma Outcome Score with net benefit and decision curve analysis

open access: yesAcademic Emergency Medicine, EarlyView.
Abstract Objective Calibration and discrimination indicators alone are insufficient for evaluating the clinical usefulness of prediction models, as they do not account for the cost of misclassification errors. This study aimed to modify the Geriatric Trauma Outcome Score (GTOS) and assess the clinical utility of the modified model using net benefit (NB)
Pawan Acharya   +5 more
wiley   +1 more source

Consumer views of functional electrical stimulation and robotic exoskeleton in SCI rehabilitation: A mini review

open access: yesArtificial Organs, Volume 49, Issue 5, Page 729-748, May 2025.
The current review synthesizes consumer perspectives regarding applications of Functional Electrical Stimulation and robotic Exoskeleton in Rehabilitation. The benefits, limitations, implantation barriers, and consumer expectations for each technology are highlighted.
Yalian Pei   +5 more
wiley   +1 more source

Outsourced eye care in the Finnish capital region: Switching from fee‐for‐service to bundled payment model

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose The demand for specialised eye care has quadrupled over the last two decades, driven by an aging population and the advent of new treatments. This surge has led to increased outsourcing by the Helsinki and Uusimaa Hospital District (HUS) Eye Hospital, initially relying on a fee‐for‐service model. This model, however, has been marked by
Susanna Moisander   +7 more
wiley   +1 more source

QUALITY CRITERIA FOR MINIMALLY MANIPULATED BIOTECHNOLOGICAL PRODUCTS BASED ON AUTOLOGOUS BONE MARROW ASPIRATE FOR USE IN TRAUMATOLOGY AND ORTHOPEDICS

open access: yesORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS
Autologous biotechnological products based on bone marrow (BM) are a source of stem cells, in particular, hematopoietic and multipotent mesenchymal stromal cells, and act as one of the alternative therapeutic agents that can slow cartilage degeneration, improve its repair and, ultimately, prevent joint replacement. Objective.
Strafun, Sergiy   +5 more
openaire   +1 more source

Factors related to resilience for mid‐ to late‐career‐stage veterinarians: a qualitative study

open access: yesAustralian Veterinary Journal, EarlyView.
Background This study aimed to explore how resilience in mid‐ to late‐career stage veterinarians in Australia is shaped by interactions between job demands, personal and contextual resources, strategies and outcomes. Methods Semistructured interviews with 17 mid‐ to late‐career stage veterinarians were conducted with questions modelled on prior ...
IF van Gelderen, SM Matthew, ML McArthur
wiley   +1 more source

Benzoyl Peroxide's Sensitisation Potential and Potency in Experimental Methods and Review of Contact Allergy and Allergic Contact Dermatitis

open access: yesContact Dermatitis, Volume 92, Issue 6, Page 436-445, June 2025.
ABSTRACT Positive patch test responses to benzoyl peroxide (BPO) have been reported from patients without and with known exposure. Up to 6.5% were found in the United States and 7.8% in a study including patients from Germany, Austria and Switzerland.
Kerstin Egele   +9 more
wiley   +1 more source

Intelligent Manufacturing for Osteoarthritis Organoids

open access: yesCell Proliferation, EarlyView.
Overall schematic of intelligent manufacturing in osteoarthritis organoids. Broad overview of the article's structure, outlining the progression from fundamental joint anatomy and OA pathogenesis to organoid construction and, ultimately, to intelligent manufacturing and future prospects.
Xukun Lyu, Jian Wang, Jiacan Su
wiley   +1 more source

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