Results 71 to 80 of about 37,216 (314)

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

FEATURES OF RETRACTION IN THE PRODUCTION OF AESTHETIC CONSTRUCTIONS

Український стоматологічний альманах, 2018
The authors of the article studied and analyzed scientific literary sources for gingival retraction in orthopedic interventions in the case of aesthetic prosthetics.
D.D. Kindiy, V.D. Kindiy, D.M. Korol, K.D. Toncheva, O.S. Shemetov, R.V. Petrenko   +5 more
doaj  

Some clinical aspects of rheumatoid arthritis [PDF]

, 1959
In our department we have been placing a special emphasis on the treatment and study of rheumatoid arthritis, and during the last four years we have handled about 1,600 cases visiting our outpatient clinic and approximately 100 hospitalized cases.
Kodama, Toshio
core   +1 more source

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

Advanced Science, EarlyView.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim, Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Jeongha Lee, Yoon Ji Jeong, Gyu Tae Park, Seongdo Jeong, Ki Won Hwang, Murim Choi, Jinhong Shin, Suck Won Hong, Jae Ho Kim   +12 more
wiley   +1 more source

Introducing a brain-computer interface to facilitate intraoperative medical imaging control – a feasibility study

BMC Musculoskeletal Disorders, 2022
Background Safe and accurate execution of surgeries to date mainly rely on preoperative plans generated based on preoperative imaging. Frequent intraoperative interaction with such patient images during the intervention is needed, which is currently a ...
Hooman Esfandiari, Pascal Troxler, Sandro Hodel, Daniel Suter, Mazda Farshad, Collaboration Group, Philipp Fürnstahl   +6 more
doaj   +1 more source

Penghasilan manual penyediaan perancangan perniagaan bagi industri kecil dan sederhana : satu kajian di Politeknik Seberang Perai [PDF]

, 2003
Kajian ini dilaksanakan untuk menentukan elemen-elemen yang bersesuaian bagi menghasilkan sebuah Perancangan Perniagaan yang lengkap dan berkesan. Fokus kajian ini ialah untuk melihat tahap pemahaman dan pengetahuan 41 orang pelajar Semester 6 Diploma
Jamaludin, Mohd Faizal
core  

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Modulating the cobalt dose range to manipulate multisystem cooperation in bone environment: a strategy to resolve the controversies about cobalt use for orthopedic applications

Theranostics, 2020
The paradoxical effect of cobalt on biological processes has aroused controversy regarding the application of cobalt-based biomaterials in bone regeneration. Tuning the dose range of cobalt ions may be a valid strategy to resolve the controversies about cobalt use for orthopedic applications.
Liu, Guanqi, Wang, Xiaoshuang, Zhou, Xuan, Zhang, Linjun, Mi, Jiaomei, Shan, Zhengjie, Huang, Baoxin, Chen, Zhuofan, Chen, Zetao   +8 more
openaire   +2 more sources

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Barnes Hospital Bulletin [PDF]

, 1989
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1272/thumbnail ...

core   +1 more source