Results 151 to 160 of about 5,946 (296)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The meaning of marriage, the meaning of family, and the function of family for Indonesian married people. [PDF]

BMC Psychol
Novianti LE, Purba FD, Puspitasari SV, Nadirah AA, Purba INB, Karremans JC, Agustiani H.   +6 more
europepmc   +1 more source

公開講演　江戸時代の随筆をめぐって

pdfThe essays in early-modern ages have the wide variety of the contents. Among these essays, there is one group which study historical evidence about the very small part of manners and customs.
日野, 龍夫, HINO, Tatsuo
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Development and verification of community development index for improving functioning of aged people in rural districts (third report): data collection and analysis system on social mutual aid are desired for community development for elderly persons living in rural districts. [PDF]

J Rural Med
Nanbu H.
europepmc   +1 more source

A multicenter analysis on the changes of sIgE in China during the early period of COVID-19 pandemic. [PDF]

Immun Inflamm Dis, 2023
Li Y, Li L.
europepmc   +1 more source

Friendly and Feejee Islands : a missionary visit to various stations in the South Seas : in the year MDCCCXLVII /

"With a map and wood-cuts.""With an appendix, containing notices of the political constitution, population, productions, manners, customs, and mythology of the people, and of the state of religion among them."Binder's title: Friendly & Feejee Islands ...
Lawry, Walter, 1793-1859., Hoole, Elijah, 1798-1872.   +1 more
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Stigma toward female smokers: gendered perceptions and moral judgment. [PDF]

BMC Psychol
Alamri I, Alamri A.
europepmc   +1 more source

Color coded health data: factors related to willingness to share health information in South Asian community members in Canada. [PDF]

Int J Popul Data Sci, 2023
Naeem I, Aroua M, Chowdhury N, Saini V, Quan H, Turin TC.   +5 more
europepmc   +1 more source