Results 81 to 90 of about 5,946 (296)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
VeredasEste artigo realiza uma leitura da sociedade de consumo, à luz da crítica corsária de Pier Paolo Pasolini, tal como ela é retratada no romance A caverna (2000), de José Saramago.
Letícia Costa Feiteira
doaj +1 more source
Manners and customs of the principal nations of the globe.
Added t.-p., engr.: Manners & customs of nations. Boston, C. H. Peirce and G. C.
Goodrich, Samuel G. (Samuel Griswold), 1793-1860.
core
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Visiones Párodicas: Risas, demonios, jocosidades y caricaturas.
Revista de Estudios Sociales, 2008 This article attempts to characterize cartoons by examining topics related to them and parody in four different moments. The frst section addresses the arrival of laughter in the Americas and the present-day territory of Colombia.
Beatriz González.
doaj
Residence, economy, and habitat in the Caroline Islands: a study in ecologic adaptation [PDF]
, 1959 This paper looks at the Caroline Islands, their social life and customs, economic conditions, manners, economics and human ecology.
Alkire, William H.
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source