Results 191 to 200 of about 173,926 (294)

Neural and psychosocial signatures of the comorbidity between pain and affective symptoms. [PDF]

open access: yesPain Rep
Scarlatti F   +27 more
europepmc   +1 more source

Impact of Preanalytical Sample Preparation on the Recovery Rate of Cryopreserved Allogeneic Hematopoietic Stem Cells

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Introduction Cryopreservation of peripheral‐blood‐derived hematopoietic stem and progenitor cells (PBSCs) has been used for decades, primarily for autologous transplantation. Now, in the era of new cellular therapies, the cryopreservation of allogeneic PBSCs may also become relevant.
Philipp Blüm   +5 more
wiley   +1 more source

Therapy and long-term outcomes of acute anal fissure: a high-volume referral centre experience with 623 patients. [PDF]

open access: yesTech Coloproctol
Fritz S   +6 more
europepmc   +1 more source

CRISPR‐Cas9 screen reveals that inhibition of enhancer of zeste homolog 2 sensitizes malignant T cells to dimethyl‐fumarate‐induced cell death

open access: yesThe FEBS Journal, EarlyView.
A genome‐wide CRISPR‐Cas9 screen identified H3K27 methylation as a key regulator of T‐cell lymphoma sensitivity to dimethyl fumarate (DMF). Specifically, inhibition of enhancer of zeste homolog 2 (EZH2) enhanced DMF‐induced cell death in malignant T cells. These results provide functional evidence for the role of EZH2 in modulating drug sensitivity and
Jan P. Teubner   +17 more
wiley   +1 more source

Targeting tumoral heterogeneity in lung cancer: a novel, CT-texture-guided targeted biopsy approach with exome sequencing. [PDF]

open access: yesNPJ Precis Oncol
Hertel A   +11 more
europepmc   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

open access: yesThe FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner   +13 more
wiley   +1 more source

Analysis of metabolic liver function and MR-morphological cholestatic parameters after SBRT of liver metastases. [PDF]

open access: yesRadiat Oncol
Dreher C   +13 more
europepmc   +1 more source

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