Results 51 to 60 of about 85,269 (245)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Local and global gravity

, 1996
Our long experience with Newtonian potentials has inured us to the view that gravity only produces local effects. In this paper we challenge this quite deeply ingrained notion and explicitly identify some intrinsically global gravitational effects.
A. W. Overhauser, D. Elizondo, D. M. Greenberger, K. G. Begeman, M. Milgrom, P. D. Mannheim, P. D. Mannheim, P. D. Mannheim, P. D. Mannheim, P. D. Mannheim, P. D. Mannheim, P. D. Mannheim, P. D. Mannheim, Philip D. Mannheim, R. Colella, R. J. Riegert, S. A. Werner, V. Perlick, W. Moreau   +18 more
core   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Some integral curves according to quasi-frame in Euclidean 3-space

Scientific African
This study explores integral curves associated with the quasi-frame in three-dimensional Euclidean space. We focus specifically on the quasi-normal and quasi-binormal vectors.
Ayman Elsharkawy, Hasnaa Baizeed
doaj   +1 more source

The Vacuole Model: New Terms in the Second Order Deflection of Light

, 2011
The present paper is an extension of a recent work (Bhattacharya et al. 2010) to the Einstein-Strauss vacuole model with a cosmological constant, where we work out the light deflection by considering perturbations up to order M^3 and confirm the light ...
A. Bhattacharya, Amrita Bhattacharya, Arunava Bhadra, C.M. Will, Ettore Laserra, G. Darmois, Guzel M Garipova, I. Smail ., I. Smail ., K. Sharon ., Kamal K Nandi, L. Page ., M. Limousin ., P.D. Mannheim, S. Pireaux, S. Weinberg, S.M. Carroll, Supernova Cosmology Project collaboration, Supernova Search Team collaboration, WMAP collaboration   +19 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

On the quaternionic Mannheim curves of Aw(k)-type in Euclidean space E3

Kuwait Journal of Science, 2015
In this paper, we consider that the curvature conditions of Aw(k)-type (1≤ k ≤ 3) quaternioniccurves in Euclidean space E3 and investigates quaternionic Mannheim curves α:I →Q withk ≠ 0 and r ≠ 0 .
SEZAI KIZILTUĞ, YUSUF YAYLI
doaj  

Scale for stratification of postoperative risk in patients with acute mechanical small bowel obstruction

Український журнал клінічної хірургії
Objective. To develop and validate a prognostic scale for patients undergoing surgery for acute mechanical small bowel obstruction. Materials and methods.
F. V. Grynchuk, V. V. Horditsa
doaj   +1 more source

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source