Results 41 to 50 of about 9,028 (148)

Real‐world effectiveness and safety with nivolumab plus ipilimumab or nivolumab alone in patients with or without melanoma brain metastasis: Results from the German noninterventional NICO study

International Journal of Cancer, EarlyView.
What's New? Although patients with melanoma brain metastases (MBM) may benefit from treatment with immune checkpoint inhibitors (ICIs), which are known to improve survival in advanced melanoma, MBM patients have often been excluded from trials evaluating ICIs.
Ralf Gutzmer, Michael Weichenthal, Thomas Eigentler, Peter Mohr, Thomas Sickmann, Pia Dücker, Christoffer Gebhardt, Sebastian Haferkamp, Katharina C. Kähler, Friedegund Meier, Claudia Pföhler, Anca Sindrilaru, Patrick Terheyden, Imke von Wasielewski, Selma Ugurel, Jens Ulrich, Jochen Utikal, Carsten Weishaupt, Dirk Schadendorf   +18 more
wiley   +1 more source

On The Second Order Mannheim Partner Curve In E3

, 2017
Mannheim curve was firstly defined by A. Mannheim in 1878.
Seyda Kılıcoglu, Senyurt, Suleyman
openaire   +1 more source

The Cancer Immunotherapy Thromboembolism Assessment: A Novel Score for Predicting Thromboembolic Events in Melanoma Patients Treated With Immune Checkpoint Inhibition

International Journal of Cancer, EarlyView.
Although immune checkpoint inhibitors (ICI) have transformed metastatic melanoma treatment, thromboembolic events (TEEs) remain a serious complication. Moreover, existing risk assessment models were developed prior to ICI use and lack clinical validation.
Tim Zell, Julian Kött, Noah Zimmermann, Greta Ancker, Alexander T. Bauer, Daniel J. Smit, Glenn Geidel, Julian C. Gerwers, Thomas Renné, Sebastian A. Wohlfeil, Jochen Utikal, Stefan W. Schneider, Christoffer Gebhardt   +12 more
wiley   +1 more source

Optimizing rapeseed protein purification: a continuous chromatographic approach for napin and cruciferin

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Napin and cruciferin, the predominant storage proteins in Brassica napus (rapeseed), exhibit favorable techno‐functional properties such as emulsification and gel formation, positioning them as promising candidates for the encapsulation and delivery of bioactive compounds. Their classification as GRAS (Generally Recognized As Safe),
Jonas Arnecke, Jessica Gillmann, Tim Börner, Mathias Hafner, Christian Frech   +4 more
wiley   +1 more source

Reward processing in children with affective dysregulation

JCPP Advances, EarlyView.
Abstract Background Affective dysregulation (AD) in children is characterized by irritability, anger, and frequent intense temper outbursts. Considerable evidence implies altered processing of frustration about missed rewards, but few studies investigated the preceding and thus potentially predictive reward anticipation and initial delivery processing ...
Pascal‐M. Aggensteiner, Francisca Giller, Nathalie Holz, Anna Kaiser, Christine Igel, Sarah Hohmann, Manfred Döpfner, Veit Roessner, Christian Beste, Tobias Banaschewski, Daniel Brandeis, on behalf ofthe ADOPT Consortium   +11 more
wiley   +1 more source

MANNHEIM CURVES IN AN N-DIMENSIONAL LORENTZ MANIFOLD [PDF]

, 2014
In this paper, we give the definition of non-null Mannheim curve and null Mannheim curve in an n-dimensional Lorentz manifold. Furthermore, we give the condition for the non-null Mannheim partner curves and the null Mannhein partner ...
Dae Won Yoon
core  

Evidence for Dark Matter Annihilation from Galactic Gamma Rays?

, 2004
The diffuse galactic EGRET gamma ray data show a clear excess for energies above 1 GeV in comparison with the expectations from conventional galactic models. The excess is seen with the same spectrum in all sky directions, as expected for Dark Matter (DM)
Aubert, Barate, Bennett, Bergstrom, Bergström, Blumenthal, Brand, Bélanger, Calcaneo-Roldan, Cesarini, de Blok, de Blok, de Boer, de Boer, Dubinski, Ellis, Faltenbacher, Fargion, Fayet, Fich, Gondolo, Haber, Helmi, Honma, Ibata, Jimenez, Jing, Jungman, Jungman, Kolb, Kuijken, Lahanus, Martínez-Delgado, Morselli, Moskalenko, Navarro, Nilles, Olling, Schneider, Siebert, Sohnius, Sparke, Spergel, Strong, Strong, Ullio, W. de Boer, Wilkinson, Yanny   +48 more
core   +3 more sources

How Can Teams Benefit From AI Team Members? Exploring the Effect of Generative AI on Decision‐Making Processes and Decision Quality in Team–AI Collaboration

Journal of Organizational Behavior, EarlyView.
ABSTRACT Human teams with distributed knowledge can make high‐quality decisions but often fail due to decision‐making asymmetries. As AI team members become integrated collaborators, understanding how AI can reduce these decision‐making asymmetries is essential. However, little is known about how AI team members can reduce these asymmetries and whether
Désirée Zercher, Ekaterina Jussupow, Ivo Benke, Armin Heinzl   +3 more
wiley   +1 more source

Updated ERNICA guidelines for the management of rectosigmoid Hirschsprung's disease 2025

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives To revise the 2018 European Reference Network for rare Inherited and Congenital Digestive and Gastrointestinal Anomalies (ERNICA) clinical guideline for the management of rectosigmoid Hirschsprung's disease (HSCR) based on new evidence and evolving clinical priorities, ensuring continued relevance, trustworthiness, and consistency ...
Daniel Rossi, Willemijn Irvine, Anna Löf Granström, Annika Mutanen, Roel Bakx, Kristin Bjørnland, Duccio Cavalieri, Piotr Czauderna, Anne Dariel, Mark Ellebæk, Francesco Fascetti Leon, Fabio Fusaro, Dirk‐Jan Gloudemans, Marietta Jank, Peter Kolja Kvist, Martin Lacher, Annette Lemli, Lucas Matthyssens, Louise Montalva, Pedro Palazon, Alessio Pini Prato, Lucie Pos, Roxana Rassouli‐Kirchmeier, Konrad Reinshagen, Nagoud Schukfeh, Rony Sfeir, Olivia Spivack, Pernilla Stenström, Lovisa Telborn, Eelke Toxopeus, Alejandra Vilanova, Miriam Wilms, Rene Wijnen, Cornelius E. J. Sloots, Mikko Pakarinen, Tomas Wester   +35 more
wiley   +1 more source

Reducing Trade‐Offs of Net Zero Carbon Transitions Through Entrepreneurship and Coordinated Innovation: A Spatially Disaggregated Analysis Across Countries and World Regions

Sustainable Development, EarlyView.
ABSTRACT Transition processes towards a sustainable future benefit from historic perspectives, since feasible changes of socio‐technological conditions and processes depend on a holistic assessment of how actors are embedded in existing institutions, routines, and structures. Building on the Income–Population–Affluence–Technology equation and utilizing
Jessica Kluge, Marcus Wagner
wiley   +1 more source