Results 91 to 100 of about 127,314 (247)
ANZ Journal of Surgery, EarlyView.ABSTRACT Background Rural residents are more likely to suffer moderate and severe traumatic brain injury (TBI) and experience delay to definitive care than urban patients. Prior studies comparing these populations were based on hospitalised patients only. We examined TBI outcomes incorporating pre‐hospital mortality to determine the association between
Gareth Rutter +4 more
wiley +1 more source
ANZ Journal of Surgery, EarlyView.ABSTRACT Background The symptomatology of large hiatus hernia (LHH) has been historically poorly understood, with cardiorespiratory symptoms caused by LHH being underappreciated by clinicians. This study reports on the mechanisms of dyspnoea in LHH through a historical review of symptoms and evolved physiological literature, discussing likely causation.
Arunan Mahendravarman +2 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu +4 more
wiley +1 more source
Cell Proliferation, EarlyView.Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao +7 more
wiley +1 more source
The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes
The FEBS Journal, EarlyView.Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova +12 more
wiley +1 more source
New ester and furocoumarins from the roots of Pituranthos tortuosus
Journal of the Brazilian Chemical Society, 2003 Seven compounds were isolated from the CHCl3 soluble fraction of the roots of Pituranthos tortuosus; in addition, mannitol was crystallized out of the total alcoholic extract.
Abdel-Kader Maged S.
doaj
The FEBS Journal, EarlyView.Vitamin B6 is a critical molecule for plant metabolism and development. Rsr4‐1, a loss‐of‐function mutant in a vitamin B6 biosynthesis gene, has a distinct short root phenotype. Here we describe five novel suppressor mutants with an rsr4‐1 background that have normalized root growth and distinct phenotypic and molecular characteristics, representing a ...
Marcelina Parra +4 more
wiley +1 more source
International Journal of Dental Hygiene, EarlyView.ABSTRACT Objectives With increasing health consciousness, the consumption of zero‐calorie beverages (zero beverages) is also increasing. Zero beverages are devoid of sugar or alternative sugar content. Tooth erosion possibility continues to be reported in cases of carbonated beverage consumption.
Eun‐Ha Jung +2 more
wiley +1 more source
Synergistic engineering of Casδ nuclease for robust genome editing
Journal of Integrative Plant Biology, EarlyView.A hierarchical engineering strategy was used to enhance the editing activity of Casδ, yielding an optimized variant termed enCasδ. This variant enables robust genome editing in animal cells and plants, with overall editing performance comparable to that of SpCas9 and other Cas12 nucleases.
Fanghui Ge +16 more
wiley +1 more source