Results 151 to 160 of about 6,998,284 (279)

Consistency of skin clearance with icotrokinra across patient subgroups with plaque psoriasis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Linda Stein Gold, April W. Armstrong, Ronald B. Vender, Jennifer Soung, Andrew E. Pink, Joseph Cafone, Bassey Effiom Edem, Ofelia Reyes‐Servin, Jingzhi Jiang, Kellen Cresswell, Cynthia M. C. DeKlotz, Megan Miller‐Kassamali, Ya‐Wen Yang, Mark G. Lebwohl   +13 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, Volume 20, Issue 11, Page 2637-2646, November 2026.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The effect of grouping on the power of the Mantel--Haenszel test for the comparison of survival rates

A criterion is found which determines, for a simple case, whether pooling observations increases or decreases the asymptotic efficiency of the Mantel--Haenszel test for treatment effect, in uncensored long term comparative trials in discrete time, under ...
Wallenstein, Sylvan, Berger, Agnes
core  

HOPE Kids 2: Phase 3, Randomized Trial of Voxelotor in Children With SCD and Conditional Cerebral Blood Flow Velocities

American Journal of Hematology, Volume 101, Issue 11, Page 2799-2811, November 2026.
ABSTRACT Children with SCD have elevated stroke risk, correlated with cerebral blood flow velocity (CBFV). HOPE Kids 2 was a phase 3, multicenter, double‐blind, placebo‐controlled trial evaluating the effect of voxelotor on CBFV. Participants aged 2 to < 15 years with SCD (HbSS/HbSβ0) and conditional CBFV (170 to < 200 cm/s) were randomized 1:1 to ...
Halima Bello‐Manga, Shehu Umar Abdullahi, Hoda Hassab, Biobele Brown, Videlis Nduba, Jessie Githanga, Adeseye Michael Akinsete, Amal El‐Beshlawy, Diana Hanna, Catherine Segbefia, Iheanyi Okpala, Azza Tantawy, Bernhards Ogutu, Venée N. Tubman, Vivian Paintsil, Yasser Wali, Mohammed Essa, Paul Telfer, Sandy Dixon, Anne Hickman, Jennifer F. Doss, Mark W. Davis, Jeremy Rupon, Fenella J. Kirkham, R. Clark Brown, on behalf of the HOPE Kids 2 Investigators, Amal El‐Beshlawy, Mohamed Badr, Diana Hanna*, Hoda Hassab, Azza Tantawy, Vivian Paintsil, Catherine Segbefia, Raffaella Colombatti, Daniela Cuzzubbo, Silverio Perrotta, Jessie Githanga, Videlis Nduba, Bernhards Ogutu, Shehu Umar Abdullahi, Adeseye Michael Akinsete, Halima Bello‐Manga, Biobele Brown, Iheanyi Okpala, Yasser Wali, Mohammed Essa, Banu Kaya, Paul Telfer, Ofelia Alvarez, Natasha Archer, Shayla Bergmann, R Clark Brown, Andrew Campbell, Carlton Dampier*, Richard Hurwitz, Erin Jackson, Janet Kwiatkowski, Melissa M. McNaull*, Venée N. Tubman   +58 more
wiley   +1 more source

Arboreality in Wild Western Lowland Gorillas (G. g. gorilla) at the Mondika Research Center, Republic of Congo

American Journal of Primatology, Volume 88, Issue 11, November 2026.
A group of western gorillas at Mondika Research Center, Republic of Congo, shifted toward lower tree strata and consumed more fruit and flowers as fruit availability increased. During low‐fruit periods, gorillas used higher strata more frequently and relied more heavily on leaves and bark.
Roberta Salmi, Rhiannon L. Schultz, Daniella DiCarlo, Jessica Lodwick, Daniel B. Hall   +4 more
wiley   +1 more source

Erroneous detection of nonuniform DIF using the Breslow-Day test in a short test

Nonuniform differential item functioning, Breslow-Day test, Three parameter logistic model, Logistic regression, Mantel–Haenszel procedure,
Horacio Attorresi, María Galibert, Pedro Prieto Marañón, María Aguerri   +3 more
core   +1 more source

Efficacy and Safety of Enlicitide in Hypercholesterolemia: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Enlicitide (MK‐0616), an oral macrocyclic peptidyl PCSK9 inhibitor, blocks the interaction between circulating PCSK9 and hepatic LDL receptors, enhancing LDL‐C clearance from the bloodstream. This systematic review and meta‐analysis of three randomized, double‐blind, placebo‐controlled trials (n = 3593) evaluated the efficacy and safety of enlicitide ...
Muhammad Farhan, Muhammad Murtaza, Muhammad Mujtaba Rasool, Farah Khan, Hammad Amjad, Kuldeep Dalpat Rai, Sheikh Muhammad Ebtehaj Ali, Ahmed Asad Raza, Muhammad Ahmad Sohail, Abedin Samadi, Furqan Hassan   +10 more
wiley   +1 more source

Risk factors of hypertension in patients from Ghana

Medisan, 2017
An analytic-observational cases and controls non paired study of 150 patients assisted in the outpatient service of Ho Municipal Hospital in the Republic of Ghana was carried out during one year (from 2013 to 2014), of which 50 suffered from hypertension
Manuel de Jesús Linares Despaigne, María Mercedes Arrate Negret, Jorge Armando Poll Pineda, Vivian Molina Hechavarría, María Elia Bell Sánchez   +4 more
doaj  

The Impact of Outcome Measures for Responder Analyses in Placebo‐Controlled Trials of Pharmacological Treatments for Neuropathic Pain

European Journal of Pain, Volume 30, Issue 10, November 2026.
ABSTRACT Background Dichotomous responder outcomes, including ≥ 30% and ≥ 50% pain reduction, patient‐reported pain relief, and Patient Global Impression of Change (PGIC), are widely used in trials assessing interventions for neuropathic pain and have been suggested to be comparable, but their differences and influence on estimated treatment effects ...
Nanna Brix Finnerup, Sandra Sif Gylfadottir, Xavier Moisset, Andrea Truini, Ralf Baron, David L. Bennett, Margarita Calvo, Daniel Ciampi de Andrade, Patrick M. Dougherty, Elena K. Enax‐Krumova, Michael C. Ferraro, Ian Gilron, Aki Hietaharju, David Hohenschurz‐Schmidt, Koichi Hosomi, Harriet I. Kemp, Ewan McNicol, Jules Phalip, Theodore J. Price, Srinivasa N. Raja, Cristina Ramirez Piriz, Andrew S. C. Rice, Blair H. Smith, Nina Taule‐Lim, Jan Vollert, Jan D. Wandrey, Mohammad D. Zunaid, Nadine Attal, Simon Haroutounian   +28 more
wiley   +1 more source

Age‐Related Patterns of Relative Energy Deficiency in Sport (REDs) Symptoms and Key Performance Factors in Adolescent Biathletes

European Journal of Sport Science, Volume 26, Issue 11, November 2026.
ABSTRACT Relative Energy Deficiency in Sport (REDs) impairs health and performance, but age‐related patterns in its emergence remain unclear. This study examines RED symptoms in adolescent biathletes at season‐start and their link to end‐of‐season performance.
Therese Fostervold Mathisen, Inger Johanne Løkkevik, Anne Mette Rustaden, Christine Sundgot‐Borgen, Lindsay Macnaughton, Helge E. Lundberg, Jorunn Sundgot‐Borgen   +6 more
wiley   +1 more source