Results 41 to 50 of about 268,751 (268)

Non-Nodal CD5-Negative Mantle Cell Lymphoma with Secondary TP53 Deletion

Case Reports in Hematology, 2020
Mantle cell lymphoma is a non-Hodgkin lymphoproliferative neoplasm with several clinical and morphologic variants linked, primarily, through genetic derangement of the cyclin D1 locus.
Robert K. McCall, Changlee S. Pang, Mark J. Pettenati   +2 more
doaj   +1 more source

RNA inhibition highlights cyclin D1 as a potential therapeutic target for mantle cell lymphoma. [PDF]

PLoS ONE, 2012
Mantle cell lymphoma is characterized by a genetic translocation results in aberrant overexpression of the CCND1 gene, which encodes cyclin D1. This protein functions as a regulator of the cell cycle progression, hence is considered to play an important ...
Shiri Weinstein, Rafi Emmanuel, Ashley M Jacobi, Avigdor Abraham, Mark A Behlke, Andrew G Sprague, Tatiana I Novobrantseva, Arnon Nagler, Dan Peer   +8 more
doaj   +1 more source

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

Science Translational Medicine, 2019
Targeting oxidative phosphorylation overcomes ibrutinib resistance in mantle cell lymphoma. Dismantling lymphoma metabolism Mantle cell lymphoma is a B cell malignancy that often responds to initial treatment with ibrutinib, an inhibitor of Bruton’s ...
L. Zhang, Yixin Yao, Shaojun Zhang, Yang Liu, Hui Guo, Makhdum Ahmed, T. Bell, Hui Zhang, Guangchun Han, E. Lorence, M. Badillo, Shouhao Zhou, Yuting Sun, M. Di Francesco, Ningping Feng, R. Haun, R. Lan, S. Mackintosh, X. Mao, Xingzhi Song, Jianhua Zhang, L. Pham, P. Lorenzi, J. Marszalek, Timmothy Heffernan, G. Draetta, Philip D. Jones, A. Futreal, K. Nomie, Linghua Wang, Michael L. Wang   +30 more
semanticscholar   +1 more source

Mantle Cell Lymphoma Presenting with Acute Bilateral Ophthalmoplegia

Türk Oftalmoloji Dergisi, 2017
A 72-year-old woman presented with acute onset of double vision, bilateral complete blepharoptosis, and nearly complete ophthalmoplegia. Orbital and brain magnetic resonance imaging were normal.
Yaran Koban, Hatice Özlece, Orhan Ayar, Mustafa Koç, Hüseyin Çelik, Zeliha Yazar, Ayşe Burcu   +6 more
doaj   +1 more source

Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management

American journal of hematology/oncology, 2019
Unprecedented advances in our understanding of the pathobiology, prognostication, and therapeutic options in mantle cell lymphoma (MCL) have taken place in the last few years.
P. Jain, Michael Wang
semanticscholar   +1 more source

Primary gastric mantle cell lymphoma

Hematology Reports, 2012
Mantle cell lymphoma represents 2,5-7% all of non Hodgkin’s lymphomas. Stomach is the most common site of extranodal lymphoma. However, that is not the case with mantle cell lymphoma, which is extremely rare.
Duska Petranovic, Gorazd Pilcic, Milena Peitl, Aleksandar Cubranic, Toni Valkovic, Antica Duletic Nacinovic, Ksenija Lucin, Nives Jonjic   +7 more
doaj   +1 more source

Update on mantle cell lymphoma.

Blood, 2018
Mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkin lymphoma that is most commonly treated with combination chemo-immunotherapy at diagnosis because of the poor prognosis. More indolent presentations have been described including patients who can
K. Maddocks
semanticscholar   +1 more source

Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma

Haematologica, 2020
Ataxia telangiectasia mutated (ATM), a critical DNA damage sensor with protein kinase activity, is frequently altered in human cancers including mantle cell lymphoma.
A. Sarkar, C. M. Stellrecht, Hima V. Vangapandu, M. Ayres, B. Kaipparettu, J. Park, K. Balakrishnan, J. Burks, T. Pandita, W. Hittelman, S. Neelapu, V. Gandhi   +11 more
semanticscholar   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis

Haematologica, 2011
Background Cases of mantle cell lymphoma with indolent behavior have been reported, but are poorly identified by current clinical risk models. Early studies found peripheral blood involvement to be an adverse prognostic factor; however, cases of a ...
Sarah L. Ondrejka, Raymond Lai, Stephen D. Smith, Eric D. Hsi   +3 more
doaj   +1 more source