Results 111 to 120 of about 8,743 (239)

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Difference and the Liberation of Sufficient Reason

European Journal of Philosophy, EarlyView.
Abstract The Principle of Sufficient Reason (PSR) holds that every event and entity can be explained by a sufficient reason or cause. Philosophers have long struggled with the question of the PSR's compatibility with freedom, for if what occurs or exists follows necessarily from its sufficient reason then it seems it could not have been otherwise ...
Louis Matheou
wiley   +1 more source

Effects of iron on the lattice thermal conductivity of Earth's deep mantle and implications for mantle dynamics. [PDF]

Proc Natl Acad Sci U S A, 2018
Hsieh WP, Deschamps F, Okuchi T, Lin JF.
europepmc   +1 more source

Effects of Body Size and Environmental Region on the Nutritional Value of Small Pelagic Species in the California Current

Fisheries Oceanography, EarlyView.
ABSTRACT We evaluated the effects of regional environment and body size on the nutritional traits of five small pelagic species differing in habitat use, feeding behavior, and importance as prey for top predators in the California Current Large Marine Ecosystem (CCLME).
Alana M. Krug‐MacLeod, Miram R. Gleiber, Elan J. Portner, C. Anela Choy, Elizabeth A. Daly, Natasha A. Hardy, Larry B. Crowder, Stephanie J. Green   +7 more
wiley   +1 more source

The Role of Upper Mantle Forces in Post‐Subduction Tectonics: Plumelet and Active Rifting in the East Anatolian Plateau

Geochemistry, Geophysics, Geosystems
The spatiotemporal interaction of large‐ and regional‐scale upper mantle forces can prevail in collisional settings. To better understand the role of these forces on post‐subduction tectonics, we focus on mantle dynamics in the East Anatolian Plateau, a ...
Ebru Şengül Uluocak, Russell N. Pysklywec, Andrea Sembroni, Sascha Brune, Claudio Faccenna   +4 more
doaj   +1 more source

“Building the Plane as We Fly It”: Examining the Current Pathways for Disclosure of Gender‐Based Violence in Sport in Australia

Gender, Work &Organization, EarlyView.
ABSTRACT This article examines how gendered institutional arrangements in Australian sport shape the reporting of gender‐based violence (GBV) against adult women and gender‐diverse people. Using feminist institutionalism, we analyze the formal and informal rules that structure sport integrity systems and the gendered power relations they reproduce ...
Samantha Marshall, Natalie Galea, Aurélie Pankowiak, Mary N. Woessner, Kirsty Forsdike   +4 more
wiley   +1 more source

A review of skin microbiome and new challenges to cosmetic microbiome‐friendly formulations

International Journal of Cosmetic Science, EarlyView.
Microbiome‐friendly concepts offer new perspectives for a healthy relationship between cosmetic use and the skin microbiome, especially the interaction of non‐biotic cosmetic ingredients with the skin, requiring further studies to clarify the dynamics between the skin microbiome and different classes of cosmetic ingredients.
Yasmin Rosa Santos, Newton Andréo‐Filho, Patricia Santos Lopes, Vânia Rodrigues Leite‐Silva   +3 more
wiley   +1 more source

Grain boundary diffusion cannot explain the W isotope heterogeneities of the deep mantle

Nature Communications
The low 182W/184W and high 3He/4He in some ocean island basalts compared to the bulk mantle values may derive from the Earth’s core through long-term core-mantle interactions. It has been proposed that the grain boundary diffusion of siderophile elements
Yihang Peng, Takashi Yoshino, Jie Deng
doaj   +1 more source

Clonal Hematopoiesis and CAR T Cell Therapy: From Biological Crosstalk to Clinical Implications

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Clonal hematopoiesis (CH) is increasingly recognized as a significant biological phenomenon in aging and cancer, marked by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations in genes associated with myeloid neoplasms.
Wei Du, Shunsuke Koga, Guang Yang, Saar Gill, Adam Bagg   +4 more
wiley   +1 more source

Ancient storage of anomalous mercury isotope signatures in the Earth’s transition zone

Nature Communications
Characterizing the mantle transition zone (MTZ) is essential for understanding Earth’s evolution and dynamics. Petrological, geochemical, and geophysical evidence suggests that the MTZ may host subducted slabs containing sediments and volatiles ...
Rong Xu, Runsheng Yin, William M. White, Michael Bizimis, Yue Cai, Junbo Zhang, Chunfei Chen, Zhendong Tian, Ting Ruan, Yibing Li, Ganglan Zhang, Liang Liu, Zhongjie Bai, Meifu Zhou, Yongsheng Liu   +14 more
doaj   +1 more source