Results 41 to 50 of about 8,743 (239)

Epidemiological Survey and Genomic Insights Into Ostreid Herpesvirus 1 Transmission in the Blood Clam Anadara broughtonii in China (2019–2025)

Animal Research and One Health, EarlyView.
Seven‐year surveillance reveals a cold‐adapted OsHV‐1 lineage in blood clams, with disease onset at 13°C—3–5°C lower than in oysters—and identifies asymptomatic carriers and facility effluent as key transmission routes. ABSTRACT Ostreid herpesvirus 1 (OsHV‐1) poses a major threat to bivalve aquaculture, but its impact on blood clams (Anadara ...
Xiang Zhang, Bowen Huang, Tao Yu, Jingli Wang, Maole Wei, Huigang Kang, Chongming Wang, Changming Bai   +7 more
wiley   +1 more source

pyMelt: An extensible Python engine for mantle melting calculations

Volcanica, 2022
Modelling the melting of Earth’s mantle is crucial for understanding the distribution of volcanic activity on Earth and for testing models of mantle convection and mantle lithological heterogeneity.
Simon Matthews, Kevin Wong, Matthew Gleeson   +2 more
doaj   +1 more source

Coherence‐Gated Wrapped‐Phase InSAR With Matrix‐Based Uncertainty Diagnostics for Burial‐Mound Hotspot Ranking (Sicily, Italy)

Archaeological Prospection, EarlyView.
ABSTRACT Burial mounds are key elements of Mediterranean funerary landscapes, but in intensively cultivated coastal plains their low‐relief expression is easily obscured by ploughing, levelling and rapidly changing surface conditions, making single‐date observations unreliable.
Salvatore Polverino, Hourakhsh Ahmadnia, Rokhsaneh Rahbarianyazd Ahmadnia   +2 more
wiley   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Constraining Mantle Viscosity Structure From a Statistical Analysis of Slab Stagnation Events

Geochemistry, Geophysics, Geosystems, 2020
The viscosity structure of Earth's mantle, even the 1‐D radial viscosity profile, remains not well constrained. The dynamics of the subducting slabs is strongly affected by, and can be used to constrain, the viscosity structure of the mantle.
Yongming Wang, Mingming Li
doaj   +1 more source

Ruthenium‐Titania Interface‐Mediated Water Activation for High Turnover Frequency in Alkaline Hydrogen Evolution

Carbon Energy, EarlyView.
Heterostructured interfaces can accelerate hydrogen evolution by improving water dissociation, yet their underlying mechanisms remain unclear. This study combines in situ Raman spectroscopy and density functional theory to reveal how the RuO2/TiO2 interface promotes both water dissociation and hydrogen adsorption, providing new insights into the ...
Dwi Sakti Aldianto Pratama, Andi Haryanto, Hyun Woo Lim, Chan Woo Lee   +3 more
wiley   +1 more source

The Rich Chemistry of Ionized Methanol With Sulfur Dioxide: Pathways to Prebiotic and Elusive Species in Earth's Atmosphere and Space

Chemistry – A European Journal, EarlyView.
The reaction between the methanol radical cation and sulfur dioxide is remarkably fast and forms several ionic and neutral products (HOSOH+, CH2OSO+, CH2OH+, CH2O, H2O, HSO2). The chemistry goes beyond simple proton or hydrogen transfer, revealing a close interaction between the two species, relevant to atmospheric and astrochemical environments where ...
Mauro Satta, Daniele Catone, Mattea Carmen Castrovilli, Antonella Cartoni   +3 more
wiley   +1 more source

Geodynamic Controls on Mantle Differentiation and Preservation of Long‐Term Geochemical Heterogeneity: Focus on the Primitive Undegassed Mantle

Geochemistry, Geophysics, Geosystems
The compositional evolution of the Earth's mantle is the result of mantle differentiation and thermal evolution. Partial melting of mantle materials produces geochemical heterogeneities, allows for degassing and depends on the thermal state of the mantle,
Nicolas Récalde, J. Huw Davies, James Panton, Don Porcelli, Morten Andersen   +4 more
doaj   +1 more source