Results 111 to 120 of about 6,153,094 (384)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

The Assessment of the Occurrence of Benign Hypermobility Joint Syndrome in Physiotherapy Students

Central European Journal of Sport Sciences and Medicine, 2017
The occurrence of connective tissue disorders is an important factor for development of occupational diseases in professions requiring a non-ergonomic and often static load of the musculoskeletal system. Symptoms of the connective tissue disorders appear
Ewelina Żyżniewska-Banaszak, Hanna Tchórzewska-Korba, Magdalena Gębska, Katarzyna Weber Nowakowska, Katarzyna Leźnicka, Kuba Żyżniewski   +5 more
doaj   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

A Calibrated Method of Massage Therapy Decreases Systolic Blood Pressure Concomitant With Changes in Heart Rate Variability in Male Rats. [PDF]

, 2017
ObjectiveThe purpose of this study was to develop a method for applying calibrated manual massage pressures by using commonly available, inexpensive sphygmomanometer parts and validate the use of this approach as a quantitative method of applying massage
Curras-Collazo, Margarita C, Dobyns, Abigail, Gutierrez, Roberto, Jha, Vidyasagar, Kaprelian, Anthony, Spurgin, Kurt A, Wilson, Christopher G, Xu, Karen H   +7 more
core   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Protocol for the saMS trial (supportive adjustment for multiple sclerosis): a randomized controlled trial comparing cognitive behavioral therapy to supportive listening for adjustment to multiple sclerosis [PDF]

, 2009
BackgroundMultiple Sclerosis (MS) is an incurable, chronic, potentially progressive and unpredictable disease of the central nervous system. The disease produces a range of unpleasant and debilitating symptoms, which can have a profound impact including ...
A Bogosian, A Janssens, A Stuifbergen, A Williams, AJ Wearden, AK Stuifbergen, AT Beck, BG Glaser, C Rogers, C Schwartz, D de Ridder, D Goldberg, D Mohr, D Mohr, D Mohr, DC Mohr, DG Altman, E Broadbent, E Godfrey, EA Hakim, G Dunn, G McIvor, H Joffe, I Boutron, I Robinson, II Kneebone, J Beecham, J Benito-Leon, J Bowen, J Brandt, J Carpenter, J Hobart, J Kurtzke, J Mundt, JE Aikens, JM Bruce, K Charmaz, KI Pakenham, KS Malcomson, L Chwastiak, L Curtis, L Dennison, L Risdale, Laura Dennison, Lucy Yardley, M Power, M Zorzon, MP McCabe, NA Brooks, National MS Society, NM Jopson, P Williams, Paul McCrone, PW Thomas, R Baron, R Emsley, RE Boyatzis, RF Antonak, RJ Siegert, Rona Moss-Morris, Sabine Landau, SB Patten, SC Hayes, SC Patten, Suzanne Roche, Trudie Chalder, UK MS Society, VG Sinclair, ZM Shnek   +68 more
core   +3 more sources

A risk–benefit assessment strategy to exclude cervical artery dissection in spinal manual-therapy: a comprehensive review

Annals medicus, 2019
Cervical artery dissection refers to a tear in the internal carotid or the vertebral artery that results in an intramural haematoma and/or an aneurysmal dilatation. Although cervical artery dissection is thought to occur spontaneously, physical trauma to
A. Chaibi, M. Russell
semanticscholar   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Manual therapy as a prophylactic treatment for migraine: design of a randomized controlled trial

Trials, 2019
Background People with migraine often experience disability with serious consequences for their social life and work productivity. The pharmacological prophylactic management of migraine is effective in reducing migraine attacks. However, many people are
Andreas Leonard Amons, Rene Franciscus Castien, Johannes C. van der Wouden, Willem De Hertogh, Joost Dekker, Henriëtte Eveline van der Horst   +5 more
doaj   +1 more source