Results 111 to 120 of about 6,094,138 (382)

The Sleep Or Mood Novel Adjunctive therapy (SOMNA) trial: a study protocol for a randomised controlled trial evaluating an internet-delivered cognitive behavioural therapy program for insomnia on outcomes of standard treatment for depression in men [PDF]

, 2015
BACKGROUND: Insomnia is a significant risk factor for depression onset, can result in more disabling depressive illness, and is a common residual symptom following treatment cessation that can increase the risk of relapse.
Christensen, Helen M., Cockayne, Nicole L., Glozier, Nick S., Griffiths, Kathleen M, Hickie, Ian B., Naismith, Sharon L., Ritterband, Lee M., Thorndike, Frances P.   +7 more
core   +2 more sources

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

A risk–benefit assessment strategy to exclude cervical artery dissection in spinal manual-therapy: a comprehensive review

Annals medicus, 2019
Cervical artery dissection refers to a tear in the internal carotid or the vertebral artery that results in an intramural haematoma and/or an aneurysmal dilatation. Although cervical artery dissection is thought to occur spontaneously, physical trauma to
A. Chaibi, M. Russell
semanticscholar   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Immediate effects of cervicothoracic junction mobilization versus thoracic manipulation on the range of motion and pain in mechanical neck pain with cervicothoracic junction dysfunction: a pilot randomized controlled trial

Chiropractic & Manual Therapies, 2020
Background Cervicothoracic (CT) junction hypomobility has been proposed as a contributing factor for neck pain. However, there are limited studies that compared the effect of CT junction mobilization against an effective intervention in neck pain ...
Shriya Joshi, Ganesh Balthillaya, Y. V. Raghava Neelapala   +2 more
doaj   +1 more source

Treatment integrity of elaborated semantic feature analysis aphasia therapydelivered in individual and group settings [PDF]

, 2017
Background & Aims This study ran within the framework of the Thales Aphasia Project that investigated the efficacy of elaborated semantic feature analysis (ESFA).
Abry, Aradi, Bellg, Boyle, Boyle, Carroll, Cherney, Cherney, Cicchetti, Clarke, Cochrane, Coelho, Cohen, Conley, Craig, Dietz, Dietz, Dusenbury, Edmonds, Edmonds, Edmonds, Egan, Faroqi-Shah, Fixsen, Gresham, Griffith, Hallgren, Heilemann, Hickey, Hinckley, Hinckley, Hoffmann, Hogue, Kaderavek, Kazdin, Kempler, Kiran, Kiran, Kiran, Kiran, Lane, Lawton, Leonard, Lichstein, Linnan, Long, Lowell, Mattis, Mcintyre, Moncher, Mowbray, Netemeyer, Papathanasiou, Peach, Perepletchikova, Raven, Rider, Rose, Rose, Rose, Rose, Rossion, Schneider, Schoenwald, Snodgrass, Stein, Stufflebeam, Sweifach, Wambaugh, Wright, Yeaton, Yoder   +71 more
core   +1 more source

The Role of Manual Therapy in Patients with COPD

Healthcare, 2019
Chronic obstructive pulmonary disease (COPD) is a respiratory condition associated with altered chest wall mechanics and musculoskeletal changes. In this narrative review, we describe the underlying musculoskeletal abnormalities in COPD, the reasons for ...
S. Clarke, P. Munro, A. Lee
semanticscholar   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Trigger point manual therapy for the treatment of chronic non-cancer pain in adults [PDF]

, 2015
This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the effectiveness of trigger point manual therapy for treating chronic non-cancer pain in ...
Brook, S, Denneny, D, Hassan, S, McLoughlin, R, Petersen, K, Williams, ACDEC   +5 more
core   +1 more source