Results 71 to 80 of about 380,691 (310)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Socio-anthropologieAt the beginning of the 19th century, the core of glassmaking craft relied on the mastery of manual transformation of materials. Throughout the century, the incorporation of new chemical and physical knowledge became essential for the production ...
Francesca Sanna
doaj +1 more source
Knjižnica, 2010 The use of cataloguing manuals is one of the key factors influencing the quality of bibliographic records. The purpose of this study is to determine the quality of a random sample of bibliographic records in the Slovenian union bibliographic/catalogue ...
Damijan Pesjak, Marija Petek
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Paḷḷivēṭṭa, or the ‘Royal Hunt’, in Prescriptive Literature and in Present-day Practice in Kerala
Cracow Indological Studies, 2014 The ritual manuals produced in Kerala are unique in their nature since most of them do not make a precise difference between the systems of Śaiva and Vaiṣṇava but rather adopt a synthesized approach.
S.A.S. Sarma
doaj +1 more source
Reconsidering Journalist Safety Training
Media and Communication, 2020 Safety training courses and manuals are designed to provide journalists with guidance to assess and mitigate risk. In this article, we ask whether content of such training and guidance is informed by actual threats and risks relevant to journalists ...
Marte Høiby, Mariateresa Garrido V.
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Instruction manuals for radiographic nondestructive testing [PDF]
, 1971 Six new handbooks on the fundamentals of nondestructive test techniques supply recent information for instructing inspectors and technicians, and can be used effectively in shops or laboratories, technical schools, or home study ...
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source