Results 91 to 100 of about 869,267 (268)

Battery Longevity in Modern Implantable Cardioverter‐Defibrillators and Cardiac Resynchronization Therapy‐Defibrillators

Journal of Arrhythmia
Background Battery longevity in high‐voltage devices (HVDs), specifically implantable cardioverter‐defibrillators (ICDs) and cardiac resynchronization therapy‐defibrillators (CRT‐Ds), is critical for reducing the frequency of generator replacements ...
Kotaro Nishino, Taro Temma, Masaya Watanabe, Motoki Nakao, Masahiro Kawasaki, Kintaro Shimano, Kei Kawakami, Shota Saito, Jiro Koya, Daishiro Tatsuta, Hiroyuki Natsui, Takuya Koizumi, Takahide Kadosaka, Taro Koya, Kiwamu Kamiya, Toshiyuki Nagai, Toshihisa Anzai   +16 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Laser shock peening of 6061-T6 aluminum alloy friction stir welding joints: Microstructure evolution, fracture morphology and strengthening mechanism

Journal of Materials Research and Technology
Enhancing the performance of Friction Stir Welding (FSW) joints is essential for improving the mechanical strength and service life of critical components in aerospace and automotive industries.
Chongjun Wu, Lingwen Chen, Jingwen Li, Xiankai Meng, Lijie Guo, Xiaosong Feng   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Enhancement of mechanical properties in TIG-welded Mg-Gd-Nd-Zn-Zr alloy via multi-step heat treatment: Regulation of grain size and precipitation behavior

Journal of Materials Research and Technology
Mg-Nd-Gd series magnesium alloys exhibit promising weldability and mechanical performance, demonstrating significant potential for aerospace applications.
Qiman Wang, Wenbing Zou, Zhiwei Chen, Zhengwu Liu, Songbin Li, Yuhuan Yin, Changjiang Chen, Huihui Zhao, Xin Tong, Guohua Wu   +9 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Manufacturing Changeability and Manufacturing as a Service

IFAC-PapersOnLine
As markets and supply chains become more volatile, rapid response to changing demands is crucial. Manufacturing as a Service (MaaS) enables quick access to manufacturing assets, while changeable manufacturing designs adaptable systems. This paper investigates how 1) manufacturing as a service may support changeability, and 2) how changeability may ...
ESLAMI, YASAMIN, Brunoe, Thomas Ditlev, da Cunha, Catherine   +2 more
openaire   +4 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source