Results 221 to 230 of about 2,561,996 (344)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

A qualitative exploration of critical issues limiting local vaccines production in Nigeria: lessons from the COVID-19 pandemic. [PDF]

BMC Public Health
Adigwe OP, Onavbavba G, Wilson DO, Adebola OJ, Ayeke A, Agu KA.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A level set-based process planning method for the additive and subtractive hybrid manufacturing of a flow channel with an inner cavity. [PDF]

Sci Rep
Li L, Xu G, Ji H, Liu Y, Li X, Cai H, Zhao S, Zou B.   +7 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Temporal Evolution, Source Apportionment, and Health Risks of Atmospheric Halocarbons: A Case Study in the Central Yangtze River Delta Region. [PDF]

Toxics
Jiang Y, Zhang A, Zou Q, Zuo H, Ding J, Zhang L, Jin L, Xu D, Niu Y, Xu B, Li X.   +10 more
europepmc   +1 more source

Design of cellular manufacturing systems

, 1996
Divakar Rajamani, N. Singh, Y.P. Aneja
openalex   +2 more sources

Comparative analysis of the gamma prime phase formation in nickel alloys in additive manufacturing

, 2020
Gleb Turichin, Olga Klimova-Korsmik, Ekaterina Valdaytseva, Andrey V. Alekseev, Mariia V Rashkovets   +4 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Optimizing energy, downtime, and throughput in footwear production through machine learning. [PDF]

Sci Rep
Sudhakar PK, Muthucumaraswamy R.
europepmc   +1 more source