Results 121 to 130 of about 1,271,617 (289)

A diagrammatic representation for entities and mereotopological relations in ontologies [PDF]

open access: yes, 2017
In the graphical representation of ontologies, it is customary to use graph theory as the representational background. We claim here that the standard graph-based approach has a number of limitations.
de Oliveira, José M. Parente   +1 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Exploration and Practice of Intelligence and Intelligent Manufacturing of Oil and Gas Engineering Equipment in China

open access: yesShiyou jixie
After decades of development,the overall level of oil and gas engineering equipment in China has entered the international advanced ranks,achieving a leap from early mechanization to automation and informatization,and then to part of digitization and ...
He Huiqun   +6 more
doaj  

Annual technical report, fiscal year 1979. Volume 1: Executive summary [PDF]

open access: yes
Accomplishments of the Point-Focusing Distributed Receiver Technology project are presented. The following aspects of the project are discussed: information dissemination, concentrator development, receiver and heat transport network development, power ...
Lucas, J. W.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Pictorial display of materials and processes aids in fabricating complex assemblies [PDF]

open access: yes, 1971
Method uses assembly consisting of single pictorial display showing cutaway view of assembly, subassemblies identified by name and materials, and processes identified by both specification and commercial design.
Ehret, R. M., Fawkes, G. J.
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

A Student-Centered Learning Approach to Design for Manufacturability: Meeting the Needs of an Often- Forgotten Customer [PDF]

open access: yes, 2018
A hands-on learning module was implemented at Marquette University in 2012 to teach biomedical engineering students about basic manufacturing processes, lean manufacturing principles, and design for manufacturability.
Goldberg, Jay R., Rank, David
core   +1 more source

Home - About - Disclaimer - Privacy