Results 121 to 130 of about 1,282,960 (310)

The Organization of New Service Development in the USA and UK [PDF]

We understand a great deal about the organization and management of new product development in the manufacturing sector, but we know relatively little about how applicable this research and practice is to the service sector.
Frank Hull, Joe Tidd
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Exploration and Practice of Intelligence and Intelligent Manufacturing of Oil and Gas Engineering Equipment in China

Shiyou jixie
After decades of development,the overall level of oil and gas engineering equipment in China has entered the international advanced ranks,achieving a leap from early mechanization to automation and informatization,and then to part of digitization and ...
He Huiqun, Zhang Hang, Ba Sha, Yu Nan, Zhang Huiyun, Wang Yida, Wang Jie   +6 more
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Virtual bloXing - assembly rapid prototyping for near net shapes [PDF]

, 2009
Virtual reality (VR) provides another dimension to many engineering applications. Its immersive and interactive nature allows an intuitive approach to study both cognitive activities and performance evaluation.
Corney, Jonathan, Lim, Theodore, Medellin, Hugo, Ritchie, James, Sung, Raymond   +4 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Annual technical report, fiscal year 1979. Volume 1: Executive summary [PDF]

Accomplishments of the Point-Focusing Distributed Receiver Technology project are presented. The following aspects of the project are discussed: information dissemination, concentrator development, receiver and heat transport network development, power ...
Lucas, J. W.
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Sectoral Innovation Systems, Corporate Strategies, and Competitiveness of the German Economy in a Globalised World [PDF]

The EU Barcelona target assumes a close causal relationship between corporate R&D, the competitiveness of business firms and the economic performance of industrial countries.
Michael Rothgang
core  

Additive manufacturing of rectangular waveguide devices for teaching microwave laboratory [PDF]

, 2019
In this paper the outline of using of low-cost additive manufacturing FDM/FFF technology to build waveguide devices is presented. The focus is set in a full design from specifications to final measurements in a microwave teaching laboratory.
Márquez-Segura, Enrique
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