Results 141 to 150 of about 295,568 (317)
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Labour Costs Versus Labour Market Development. Empirical evidence for Polish, Czech and Hungarian manufacturing industry [PDF]
The paper analyses the relationship between labour costs and employment development in manufacturing industry in Poland, Czech Republic and Hungary. It indicates the need for thorough labour cost analysis in Europe in the context low employment rates ...
: Agnieszka Furmanska-Maruszak
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Determinants of Foreign Direct Investment in the Food Manufacturing Industry
This paper examines firm-specific characteristics in the food manufacturing industry that affect firms' decisions in accessing foreign markets via foreign direct investment (FDI). It also seeks to assess variations in the intensity level of multinational
Wendt, Minh, Pederson, Glenn D.
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Integrating Lean Manufacturing and Industry 4.0 for Enhanced Operational Performance [PDF]
openThis thesis examines the integration of Lean Manufacturing principles with Industry 4.0 technologies and their combined impact on organizational performance. The first chapter provides a brief overview of Lean manufacturing.
FILIPUZZI, GIULIA
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Hybrid design based on wire and arc additive manufacturing in the aircraft industry [PDF]
, 2012 Wire and Arc Additive Manufacturing (WAAM) is a developing rapid prototyping and manufacturing technology which allows the production of large custom-made metal parts with high deposition rates, a major concern of the aircraft industry.
Chen, Jian
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source