Results 41 to 50 of about 1,028,816 (310)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Sustainability in Manufacturing Strategy Deployment
Procedia CIRP, 2015 AbstractThe focus of the paper is the development of a reference model for manufacturing strategy implementation. While many empirical research endeavors report the lack of vigor in implementing sustainability as a manufacturing strategy, also current popular theory-driven approaches are not sufficient to understand the dynamics and organizational ...
TAISCH, MARCO +2 more
openaire +2 more sources
Industrial waste management within manufacturing: a comparative study of tools, policies, visions and concepts [PDF]
, 2013 Industrial waste is a key factor when assessing the sustainability of a manufacturing process or company. A multitude of visions, concepts, tools, and policies are used both academically and industrially to improve the environmental effect of ...
Bjelkemyr, Marcus +4 more
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Manufacturing strategy issues in selected Indian manufacturing industry [PDF]
, 2013 This paper presents some findings of Indian manufacturing sectors viz. automobile (especially two-wheeler), tractor and general manufacturing industry.
Mahender Singh, P.C. Basak, Rajbir Singh
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Competitive manufacturing strategies for the manufacturing industries in Turkey [PDF]
, 2003 In this study, results of the research into competitive manufacturing strategies of companies in four different sector studies covering 82 companies from the electronics, cement, automotive manufacturers, and appliances part and component suppliers in ...
Ulusoy, Gunduz, Ulusoy, Gündüz
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source