Results 241 to 250 of about 6,428,242 (364)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Impact of caffeine consumption on headache severity, sleep quality, and psychiatric symptoms in patients with idiopathic intracranial hypertension: a cross-sectional study. [PDF]

J Headache Pain
Abdelghaffar M, Hussein M, Magdy R, Elgenidi A, Dahshan A, Taha NA, Merghany N, Essmat A, Hassan A, Moustafa RR, Fayez MM, Nasser AMA, Yacoub O.   +12 more
europepmc   +1 more source

The difficult task of finding digitized music manuscripts in online library collection

, 2020
Juliane Peetz-Ullman
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Effects of two work-to-rest ratios on physiological, neuromuscular, and RPE responses during taekwondo-specific HIIT. [PDF]

BMC Sports Sci Med Rehabil
Zheng H, Zhang G, Zhong Y, Yin M, Gu Z, Wang X, Zeng X, Nassis GP, Li Y.   +8 more
europepmc   +1 more source

S. MITCHELL, "The Treaty Between Rome and Lycia of 46 BC" (MS 2070). Ed. Rosario PINTAUDI. Papyrologica Florentina XXXV (2005) 163-258. Papyri Graecae Schøyen [Manuscripts in The Schøyen Collection V: Greek papyri, vol. I], Firenze.

, 2015
Tori Duggan
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Sex-specific cypermethrin-induced hippocampal neurotoxicity is associated with alterations in signaling molecules for antioxidant defense, membrane integrity, apoptosis, and GABAergic integrity. [PDF]

BMC Neurosci
Imam A, Busari M, Oyegbola C, Moyinoluwa BF, Faith O, Samuel APG, Ibrahim IB, Atiyatul-Hanan GT, Iyiola AM, Ijomone OM, Ajao MS.   +10 more
europepmc   +1 more source