Results 131 to 140 of about 161,880 (308)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Intermediate Remains. What Unfinished Miniatures Tell us about the Use of Pattern Sheets in Late Medieval Manuscript Illumination

, 2018
Heyder JC. Intermediate Remains. What Unfinished Miniatures Tell us about the Use of Pattern Sheets in Late Medieval Manuscript Illumination. In: Terrier Aliferis L, Borlée D, eds. Les modèles dans l’art du Moyen Âge (XIIe-XVe siècles).
Borlée, Denise, Terrier Aliferis, Laurence, Heyder, Joris C.   +2 more
core  

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Full vision adaptation in mixed-light conditions enabled by dynamic water adsorption/desorption. [PDF]

Nat Commun
Zhu J, Liu W, Huang W, Chen X, Feng X, Luo X, Xu K, Gao M, Ling H, Song C, Cheng H, Lin Y.   +11 more
europepmc   +1 more source

Exploration of The Meaning of Animal Figures in The Illumination of The Jayalengkara Wulang Jav 24 Manuscript

This research aims to investigate the significance of the interpretation of the animal element in the manuscript Jav 24, which contains the text Jayalengkara Wulang, and its relevance to the main doctrine of Javanese leadership, namely Asta Brata.
Dwiadmojo, Ghis Nggar, Hartanto, Doni Dwi, Ekowati, Venny Indria, Mulyani, Hesti   +3 more
core   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

Judith H. Oliver, Gothic Manuscript Illumination in the Diocese of Liège (ca. 1250-ca. 1330), Corpus of Illuminated Manuscripts from the Low Countries, Louvain, 1988, 518 p.

, 1994
Stirnemann Patricia. Judith H. Oliver, Gothic Manuscript Illumination in the Diocese of Liège (ca. 1250-ca. 1330), Corpus of Illuminated Manuscripts from the Low Countries, Louvain, 1988, 518 p.. In: Bulletin Monumental, tome 152, n°3, année 1994.
Stirnemann, Patricia
core   +1 more source

Low-Light Monocular Depth Estimation Algorithm Based on Illumination Adaptive Image Enhancement. [PDF]

Sensors (Basel)
Cao X, Wang Y, Li W, Liu W.
europepmc   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

Scleral Transillumination-Guided Trocar Placement During Vitrectomy in Highly Myopic Eyes: A Case Report. [PDF]

Cureus
Takagi K, Ohtani H, Ida C, Sugihara K, Tanito M.   +4 more
europepmc   +1 more source