Results 61 to 70 of about 6,084,288 (305)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Mistakes and the study of manuscripts
Calenda, 2016 Les fautes, les erreurs, les ratures et autres éléments de ce type que les manuscrits contiennent, mettent parfois en lumière les acteurs des opérations menées pour produire ces manuscrits. Comment reconnaître une faute, une erreur, et semblables phénomènes ? Que pouvons-nous apprendre des caractéristiques de ces objets ? Peut-on proposer une typologie
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Exploring the needs of Malay manuscript studies community for an e-learning platform [PDF]
, 2011 Philology studies are often associated with traditional methods of teaching and learning. This study explores the possibility of e-learning adoption amongst Malay manuscripts learning community.
Zainab, A.N. +6 more
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KHOREZM KHALPHA STUDIES: MANUSCRIPT SOURCES AND THEIR STUDY
, 2022 This article deals with the historical roots of the Khorezmkhalpha studies, manuscript sources and their study. Khalfa songs, in general, have played an important role in the recording of folk songs, as well as musicologists, and research in folklore has
Ergashevna, Sabirova Nasiba
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Literary Collectors as Literary Scribes: The Case of Đuro Ferić (1739–1820)
Poznańskie Studia Slawistyczne, 2018 The essay reconstructs the scribal collection of Ragusan literature compiled by Đuro Ferić (1739–1820) and currently scattered across various libraries.
Ivan Lupić, Irena Bratičević
doaj +1 more source
Programme Of Studies In Oriental Manuscripts
, 2012 Project presentation: Programme of Studies in Oriental ...
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Miranda: Revue Pluridisciplinaire du Monde AnglophoneAlthough regularly mentioned in suicide studies, the anonymous manuscript “Whether it be dampnation for a man to kill hym self” (1578) – often attributed to John Harington – was seldom regarded as a textual production in its own right.
Irène Vilquin
doaj +1 more source