Results 101 to 110 of about 1,512,865 (300)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Comparing background elimination approaches for processing of ancient Thai manuscipts on palm leaves [PDF]

open access: yes, 2009
The objective of the Preservation of Palm Leaf Manuscripts Project at Mahasarakham University at Thailand is to preserve and retrieve traditional knowledge from ancient manuscripts recorded on palm leaves. An essential task in the process is to recognize
Fung, C.C.   +3 more
core   +1 more source

Buddhist Approach to the Ethical Analysis of Premeditated Murder

open access: yesRUDN Journal of Philosophy
The purpose of the research is to explicate the Buddhist principles of ethical analysis of premeditated murder as an immoral act. The author solves this problem through the method of case study of exegetical treatises of outstanding Buddhist thinkers ...
Helena P. Ostrovskaya
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Сommunicative Discourse of Tattvasaṅgrāha by Śāntarakṣita

open access: yesRUDN Journal of Philosophy
The study provides an insight into the structural features of the famous VIII century Buddhist treatise Tattvasaṅgrāha by Śāntarakṣita with regard to the text’s main purpose ( prayojana ) as it is treated in Kamalaśīla’s commentary Pañjikā .
Vladimir P. Ivanov
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Byzantine book epigrams from manuscripts to a digital database

open access: yes, 2012
Byzantine manuscripts contain, apart from ancient or medieval ‘literary’ texts, also poetic texts that are intimately related to the production of the manuscript itself, and that can be considered as ‘poetic paratexts’.
Meizoz, Jérômeeditor   +5 more
core  

PAGES FROM THE ASHGABATPERIOD OF LIFE OF ORIENTALIST A.A. SEMENOV - NATIVE OF SHATSKS VILLAGE POLNOE KОNОBЕЕVО

open access: yesНеофилология, 2016
On the basis of the analysis still the non-published memoirs of eyewitnesses of events and the written certificates containing in the published literature, some pressing questions connected with life and activity of visible scientist-orientalist ...
Muradgeldi Soyegov
doaj  

Historiography of Yogācāra Philosophy in 20th Century India

open access: yesRUDN Journal of Philosophy
Paradigms of historiography of philosophy in India have being changed since late 19th c. till present, depending on the social and cultural context of the history of Indian philosophy as a part of contemporary Indian culture. This change manifests itself
Sergei L. Burmistrov
doaj   +1 more source

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