Results 41 to 50 of about 8,214,233 (250)

Algorithm for constructing logical operations to identify patterns in data [PDF]

open access: yesE3S Web of Conferences, 2020
Neural networks have proven themselves in solving problems when the input and output data are known, but the cause and effect relationship between them is not obvious.
Lyutikova L.A., Shmatova E. V.
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Non-Clausal Multi-ary α-Generalized Resolution Calculus for a Finite Lattice-Valued Logic

open access: yesInternational Journal of Computational Intelligence Systems, 2018
Due to the need of the logical foundation for uncertain information processing, development of efficient automated reasoning system based on non-classical logics is always an active research area.
Yang Xu   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Linear Abelian Modal Logic

open access: yesBulletin of the Section of Logic
A many-valued modal logic, called linear abelian modal logic \(\rm {\mathbf{LK(A)}}\) is introduced as an extension of the abelian modal logic \(\rm \mathbf{K(A)}\). Abelian modal logic \(\rm \mathbf{K(A)}\) is the minimal modal extension of the logic of
Hamzeh Mohammadi
doaj   +1 more source

Theorem proving for prenex G\"odel logic with Delta: checking validity and unsatisfiability [PDF]

open access: yesLogical Methods in Computer Science, 2012
G\"odel logic with the projection operator Delta (G_Delta) is an important many-valued as well as intermediate logic. In contrast to classical logic, the validity and the satisfiability problems of G_Delta are not directly dual to each other.
Matthias Baaz   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Propositional Gödel logic, Delannoy paths and ordered partitions

open access: yes, 2006
Goedel propositional logic is the logic of the minimum t-norm, and can be axiomatised as propositional intuitionistic logic augmented by the prelinearity axiom.
P. Codara
core   +2 more sources

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