T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
On many-valued modal logics and uncertainty logics for many-valued events
, 2017 Peer ...
openaire +1 more source
Advanced Science, EarlyView.The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob +12 more
wiley +1 more source
New Representation Theorem for Many-valued Modal Logics
, 2008 We propose a new definition of Representation theorem for many-valued modal logics, based on a complete latice of algebraic truth values, and define the stronger relationship between algebraic models of a given logic L and relational structures used to ...
core
A Scoping Review of the Conceptualization, Operationalization, and Institutional Recognition of the Scholarship of Teaching and Learning in Health Professions Education: Using Institutional Logics to Understand Inconsistencies. [PDF]
Perspect Med EducVarpio L +8 more
europepmc +1 more source
An Integrated NLP‐ML Framework for Property Prediction and Design of Steels
Advanced Science, EarlyView.This study presents a data‐driven framework that uses language‐processing techniques to interpret steel processing descriptions and machine‐learning models to predict mechanical properties. By organising complex process histories into meaningful groups and enabling rapid property forecasts, the work supports faster, more informed steel design through ...
Kiran Devraju +5 more
wiley +1 more source
, 2012 The present essay includes six thematically connected papers on negation in the areas of the philosophy of logic, philosophical logic and metaphysics. Each of the chapters besides the first, which puts each the chapters to follow into context, highlights
De, Michael
core
Proof theory for locally finite many-valued logics: Semi-projective logics.
Theor Comput Sci, 2013 Ciabattoni A, Montagna F.
europepmc +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
Mapping the “Supply–Demand–Flow” of Ecosystem Services for Ecosystem Management in China
Advanced Science, EarlyView.This study develops a “supply–demand–flow” framework clarifies how ecosystem services move between regions by distinguishing potential and actual supply and demand. Using integrated biophysical–socioeconomic modeling, nine services in China were mapped.
Yikun Zhang +3 more
wiley +1 more source