Results 101 to 110 of about 1,378,682 (321)

Evidence that Formulations of the Selective MAO-B Inhibitor, Selegiline, which Bypass First-Pass Metabolism, also Inhibit MAO-A in the Human Brain

Neuropsychopharmacology, 2014
Selegiline (L-deprenyl) is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B) at the conventional dose (10 mg/day oral) that is used in the treatment of Parkinson’s disease.
J. Fowler, J. Logan, N. Volkow, E. Shumay, F. McCall-Perez, Millard Jayne, Gene-Jack Wang, D. Alexoff, Karen Apelskog-Torres, Barbara Hubbard, P. Carter, P. King, S. Fahn, M. Gilmor, F. Telang, C. Shea, Youwen Xu, L. Muench   +17 more
semanticscholar   +1 more source

Multi‐Material Additive Manufacturing of Soft Robotic Systems: A Comprehensive Review

Advanced Robotics Research, EarlyView.
This review explores the transformative role of multi‐material additive manufacturing (MMAM) in the development of soft robotic systems. It presents current techniques, materials, and design strategies that enable functionally graded and adaptive structures.
Ritik Raj, Quan‐Chen Song, Jia‐Yang Juang   +2 more
wiley   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

The Electrochemical and Corrosion Behavior of Biocompatible Magnesium Alloy in simulated body fluid [PDF]

, 2014
poster abstractMagnesium alloys are newly promising biomaterials for human bone replacement or repair. However, magnesium alloy need more resistant to corrosion when it is implant in human body.
Liu, Jiayang
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Monoamine Oxidase Inhibitory Constituents of Propolis: Kinetics and Mechanism of Inhibition of Recombinant Human MAO-A and MAO-B

Molecules, 2014
Propolis is the resinous material that bees gather from leaf buds, flowers and vegetables. Propolis extracts contain constituents with a broad spectra of pharmacological properties and are important ingredients of popular dietary supplements.
N. D. Chaurasiya, M. Ibrahim, I. Muhammad, L. Walker, B. Tekwani   +4 more
semanticscholar   +1 more source

Hyperelastic Starch Hydrogel Configures Edible and Biodegradable All‐Components for Soft Robots

Advanced Science, EarlyView.
Hyperelastic starch hydrogel is tailored via a phase separation strategy of solvent‐antisolvent co‐modulation. The mechanical performance of starch hydrogel is widely tuned with maximum strains: 194.4–361.4%; maximum tensile stresses: 34–192 kPa; and Young's moduli: 36.0–205.8 kPa. Notably, the hydrogel achieves complete soil degradation within 24 days
Siyu Yao, Haohao Hu, Mengfan Zhang, Qingqing Zhu, Donghong Liu, Shaoxing Qu, Guoyong Mao, Enbo Xu   +7 more
wiley   +1 more source

Tha synthesis of syndiotactic polystyrene using monocyclopentadienyl titanium complexes [PDF]

, 2008
Série čtyř nových halosilylsubstituovaných monocyklopentadienylových komplexů titanu [Si(CH3)2FCp]TiCl3 – FSiTTC, [Si(CH3)F2Cp]TiCl3 F2SiTTC, [Si(CH3)Cl2Cp]TiCl3 - Cl2SiTTC, [Si(CH3)2ClCp]TiCl3 - ClSiTTC byla po aktivaci methylalumoxanem testována jako ...
Svačina, Zdeněk
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Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Mequindox Induced Genotoxicity and Carcinogenicity in Mice

Frontiers in Pharmacology, 2018
Mequindox (MEQ), acting as an inhibitor of deoxyribonucleic acid (DNA) synthesis, is a synthetic heterocyclic N-oxides. To investigate the potential carcinogenicity of MEQ, four groups of Kun-Ming (KM) mice (50 mice/sex/group) were fed with diets ...
Qianying Liu, Qianying Liu, Zhixin Lei, Qin Wu, Deyu Huang, Shuyu Xie, Shuyu Xie, Xu Wang, Xu Wang, Yuanhu Pan, Yuanhu Pan, Zonghui Yuan, Zonghui Yuan, Zonghui Yuan, Zonghui Yuan   +14 more
doaj   +1 more source

Mao Chen. Between tradition and change : the hermeneutics of May Fourth literature

, 1998
This article reviews the book Between Tradition and Change: The Hermeneutics of May Fourth Literature , written by Mao ...
STEVENS, Sarah E.
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