Results 131 to 140 of about 1,018,353 (274)

Xiaomei Chen. Occidentalism : a theory of counter-discourse in Post-Mao China

open access: yes, 1998
This article reviews the book Occidentalism: A Theory of Counter-Discourse in Post-Mao China , written by Xiaomei ...
MORAN, Thomas
core  

Patient‐Derived 3D‐Bioprinted Intrahepatic Cholangiocarcinoma Models Recapitulate Tumor Autologous Traits and Predict Personalized Adjuvant Therapy

open access: yesAdvanced Science, EarlyView.
Leveraging 3D bioprinting, this study establishes patient‐derived in vitro models of intrahepatic cholangiocarcinoma. These models faithfully recapitulate the histopathology, molecular profiles, and genomic characteristics of the original patient tumors.
Yuce Lu   +23 more
wiley   +1 more source

A Polymer‐Intercalated Modulation Assembly Strategy Towards Mesoporous Single‐Crystalline BiVO4 Materials for Enhanced Photocatalytic Performance

open access: yesAdvanced Science, EarlyView.
A polymer‐intercalated modulation assembly strategy was proposed to synthesize mesoporous single‐crystalline BiVO4 with tunable pore structure by co‐assembly of inorganic–organic composite through coordination bonds and hydrogen bonds. Thanks to single‐crystalline properties and mesoporous structure with vanadium vacancy microenvironment, the prepared ...
Wei Li   +6 more
wiley   +1 more source

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

open access: yesAdvanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang   +10 more
wiley   +1 more source

Illuminating Mitochondrial RNA G‐Quadruplexes as Structural Brakes on RNA Granule Assembly and OXPHOS

open access: yesAdvanced Science, EarlyView.
A new fluorescent probe, MitoQUMA, brings mitochondrial RNA G‐quadruplexes (mtRNA G4s) into view in live cells. This tool reveals that excessive mtRNA G4 formation halts mitochondrial RNA granule (MRG) assembly, opposite to the phase‐separation role of cytoplasmic RNA G4s. A chemical genetic screen further identifies a Wnt/β‐catenin–GRSF1–mtRNA G4 axis
Gui‐Xue Tang   +7 more
wiley   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

open access: yesAdvanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin   +5 more
wiley   +1 more source

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

open access: yesAdvanced Science, EarlyView.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li   +8 more
wiley   +1 more source

Synergistic Intra‐ and Inter‐Nanozyme Electron Transfer through Interfacial Assembly for Enhanced Multi‐Enzyme Activity

open access: yesAdvanced Science, EarlyView.
A novel Prussian blue‐based composite nanoenzymes (PB C‐NZs)‐MoS2/PB, was designed based on the electron transfer mechanism and transport pathway. The structure uses MoS2 as the substrate, with PB grown on its surface through a surface assembly method.
Kun Lu   +7 more
wiley   +1 more source

A smart headband for multimodal physiological monitoring in human exercises

open access: yesAdvanced Science, EarlyView.
A novel smart headband incorporating a thermal‐sensation‐based electronic skin is presented for continuous and accurate multimodal physiological monitoring, including pulse waveforms, total metabolic energy expenditure, heart rate, and forehead temperature, across both static and dynamic daily activities.
Shiqiang Liu   +7 more
wiley   +1 more source

Exceptional Antimodes in Multi‐Drive Cavity Magnonics

open access: yesAdvanced Electronic Materials, EarlyView.
Driven‐dissipative cavity‐magnonics provides a flexible platform for engineering non‐Hermitian physics such as exceptional points. Here, using a four‐port, three‐mode system with controllable microwave interference, antimodes and coherent perfect extinction (CPE) are realized, enabling active tuning to antimode exceptional points.
Mawgan A. Smith   +4 more
wiley   +1 more source

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