Results 71 to 80 of about 1,378,682 (321)

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis [PDF]

, 2019
A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted (hetero)aromatic substituents
Alcaro, Stefano, Bagetta, Donatella, Carradori, Simone, Chimenti, Paola, D’Ascenzio, Melissa, Guglielmi, Paolo, Ortuso, Francesco, Petzer, Anél, Petzer, Jacobus P., Secci, Daniela, Zengin, Gokhan   +10 more
core   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

Optimal regimens based on PK/PD cutoff evaluation of ceftiofur against Actinobacillus pleuropneumoniae in swine

BMC Veterinary Research, 2020
Background Actinobacillus pleuropneumoniae formerly known as Haemophilus pleuropneumoniae, can cause pleuropneumoniae in pigs, which lead to significant mortality.
Da Sun, Kun Mi, Haihong Hao, Shuyu Xie, Dongmei Chen, Lingli Huang   +5 more
doaj   +1 more source

Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States

Advanced Healthcare Materials, EarlyView.
This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao, Ao Zheng, Zhengyan Zhao, Qilin Li, Tianhao Wan, Tanjun Deng, Ying Zhang, Lingyan Cao, Lan Wu   +8 more
wiley   +1 more source

Distribution and genetic characterization of fluoroquinolone resistance gene qnr among Salmonella strains from chicken in China

Microbiology Spectrum
The prevalence and dissemination of the plasmid-mediated fluoroquinolone (FQ) resistance gene qnr in Salmonella are considered serious public health concerns worldwide.
Yang Chen, Lihui Liu, Yali Guo, Jinhua Chu, Bangjuan Wang, Yuxin Sui, Hanqi Wei, Haihong Hao, Lingli Huang, Guyue Cheng   +9 more
doaj   +1 more source

NO THE HOLMBERG EFFECT FOR GALAXY PAIRS SELECTED FROM THE SDSS DR9 AT Z ≤ 0:06

Odessa Astronomical Publications, 2016
We studied the Holmberg effect in galaxy pairs selected from the SDSS DR9, where 60561galaxies were limited by redshift 0.02 < z < 0.06 and absolute magnitude: Mr ≤ −20.7 m for central galaxies (N=18578) and Mr > −21.5 m for neighbor galaxies (N=41983 ...
D. V. Dobrycheva, I. B. Vavilova
doaj   +1 more source

Asymptotic stability of stochastic differential equations driven by Lévy noise [PDF]

, 2009
Using key tools such as Ito's formula for general semimartingales, Kunita's moment estimates for Levy-type stochastic integrals, and the exponential martingale inequality, we find conditions under which the solutions to the stochastic differential ...
David Applebaum, Michailina Siakalli, Cont, Øksendal, Mao, Hardy, Mao, Burkill, Mao, Mao   +9 more
core   +1 more source

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source

Investigating gilding techniques on Gandharan stone sculptures and architectural components: a preliminary note

Restauro Archeologico, 2019
Taking into account the reports on archaeological excavation and the resulting successive publications, the present article wants to define the exact place of origin and an accurate dating for a schist bracket showing traces of gilding, currently ...
Claudia Ramasso
doaj   +1 more source