Results 71 to 80 of about 326,872 (306)
A synthetic antibiotic class with a deeply-optimized design for overcoming bacterial resistance
Nature CommunicationsThe lack of new drugs that are effective against antibiotic-resistant bacteria has caused increasing concern in global public health. Based on this study, we report development of a modified antimicrobial drug through structure-based drug design (SBDD ...
Jin Feng +7 more
doaj +1 more source
Restauro Archeologico, 2019 Taking into account the reports on archaeological excavation and the resulting successive publications, the present article wants to define the exact place of origin and an accurate dating for a schist bracket showing traces of gilding, currently ...
Claudia Ramasso
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan +12 more
wiley +1 more source
Expression regulation of MAO isoforms in monocytic cells in response to Th2 cytokines
, 2005 Background: Th2-cytokines, such as interleukins-4 and –13 (IL-4, IL-13), have been identified as alternative stimuli of monocytes/macrophages. We have recently profiled the gene-expression pattern of IL-4-teated human peripheral monocytes and found that ...
Kuban, RJ +4 more
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M2004-004: Calligraphy Poem by Mao Zedong
, 2023 Poem by Mao Zedong in calligraphy. Black ink on white silk. Silk is embroidered with demask/ floral patterning along the edges. Silk is cream in color.
Zedong, Mao
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Measurement of MAO Enzymatic Activity by Spectrophotometric Direct Assays
, 2023 : MAO activity measurement can be monitored by direct peroxidase-free assays following different spectroscopy methods. Typically, these are assays that follow the conversion of different MAO substrates into its corresponding products monitored in either ...
Reis, Joana, Binda, Claudia
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Advanced Science, EarlyView.This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou +12 more
wiley +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
Advanced Science, EarlyView.Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng +11 more
wiley +1 more source
, 1977 An autobiographical look at the life and influence of Mao Zedong, Marxist theorist, soldier, and statesman. The commentary of this film is exclusively composed of excerpts from Mao Tsê-tung's speeches and writings, published by the Red Guard during the ...
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