Results 51 to 60 of about 2,289,454 (296)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A Multi-Scale Residential Areas Matching Method Considering Spatial Neighborhood Features
ISPRS International Journal of Geo-Information, 2022 Residential areas is one of the basic geographical elements on the map and an important content of the map representation. Multi-scale residential areas matching refers to the process of identifying and associating entities with the same name in ...
Jingzhen Ma +4 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Dense spatio‐temporal stereo matching for intelligent driving systems
IET Image Processing, 2021 This paper addresses the problem of matching stereo images acquired by a stereo system mounted aboard an intelligent vehicle. The main idea behind the new method consists in involving temporal matching between a current stereo pair and its preceding one ...
Zakaria Kerkaou +3 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Map Matching and Lanes Number Estimation with Openstreetmap [PDF]
2018 21st International Conference on Intelligent Transportation Systems (ITSC), 2018 Road information, like lanes number, play an important role for intelligent vehicles (IV). Traditionally such road information are obtained through a vision-based measurement or by using a digital detailed map. In this paper, we present a new method for estimating the number of lanes using a low precision GPS receiver and OpenSteetMap (OSM). The method
Kasmi, Abderrahim +3 more
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Map Matching with Simplicity Constraints
CoRR, 2013 We study a map matching problem, the task of finding in an embedded graph a path that has low distance to a given curve in R^2. The Fréchet distance is a common measure for this problem. Efficient methods exist to compute the best path according to this measure. However, these methods cannot guarantee that the result is simple (i.e.
openaire +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source