Results 61 to 70 of about 3,304,339 (314)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Sulu Archipelago 1:50,000 [cartographic material] /

, 1944
1st ed. (AMS 1). Topographic maps of the Sulu Archipelago, Philippines. Relief shown by soundings, spot heights, contours, and form lines where shown at approximately 100 foot intervals, heights and depths in feet.; Standard map series designation ...
United States. Army Map Service.
core  

Improving ways of working with researchers with lived expertise (of homelessness)

Research Involvement and Engagement
It has become increasingly apparent that conducting rigorous, relevant and accepted research requires including Researchers with Lived Expertise/Experience (RWLE) in the research process. Including RWLE can create new knowledge rooted in new perspectives,
Frank Crichlow, Allison Patrice Dyer, Jesse Isadora Reisman Jenkinson   +2 more
doaj   +1 more source

Rapid, Affordable and Efficient Screening of Multiple Blood Abnormalities Made Possible Using an Automated Tool for MALDI-ToF Spectrometry Analysis

Applied Sciences, 2019
Screening programs for genetic and metabolic diseases such as haemoglobinopathies, thalassemias and diabetes are a worldwide problem that faces economic and technological limitations.
Ricardo J. Pais, Christian Jardine, Raminta Zmuidinaite, Jonathan Lacey, Steve Butler, Ray Iles   +5 more
doaj   +1 more source

Dental problems and chronic diseases in mentally ill homeless adults: a cross-sectional study

BMC Public Health, 2020
Background Dental problems (DPs) and physical chronic diseases (CDs) are highly prevalent and incident in people with low socioeconomic status such as homeless individuals.
Cilia Mejia-Lancheros, James Lachaud, Rosane Nisenbaum, Andrea Wang, Vicky Stergiopoulos, Stephen W. Hwang, Patricia O’Campo   +6 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Korea 1:250,000 [cartographic material] /

, 1950
1st ed. - AMS. "Constructed and molded from Korea 1:250,000 AMS L552."; Each map is individually titled by area and numbered within the series.; Topographic raised relief model map series of Korea showing populated places, roads, railroads, international
United States. Army Map Service.
core  

Enhancing detection of SARS-CoV-2 re-infections using longitudinal sero-monitoring: demonstration of a methodology in a cohort of people experiencing homelessness in Toronto, Canada

BMC Infectious Diseases
Background Accurate estimation of SARS-CoV-2 re-infection is crucial to understanding the connection between infection burden and adverse outcomes. However, relying solely on PCR testing results in underreporting.
Lucie Richard, Rosane Nisenbaum, Karen Colwill, Sharmistha Mishra, Roya M. Dayam, Michael Liu, Cheryl Pedersen, Anne-Claude Gingras, Stephen W. Hwang   +8 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source