Results 81 to 90 of about 16,648,047 (271)

Maximum aposteriori joint source/channel coding [PDF]

open access: yes
A maximum aposteriori probability (MAP) approach to joint source/channel coder design is presented in this paper. This method attempts to explore a technique for designing joint source/channel codes, rather than ways of distributing bits between source ...
Gibson, Jerry D., Sayood, Khalid
core   +1 more source

A sequential sampling strategy for extreme event statistics in nonlinear dynamical systems

open access: yes, 2018
We develop a method for the evaluation of extreme event statistics associated with nonlinear dynamical systems, using a small number of samples. From an initial dataset of design points, we formulate a sequential strategy that provides the 'next-best ...
Mohamad, Mustafa A.   +1 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

A Lightweight and Flexible Mobile Agent Platform Tailored to Management Applications

open access: yes, 2011
Mobile Agents (MAs) represent a distributed computing technology that promises to address the scalability problems of centralized network management. A critical issue that will affect the wider adoption of MA paradigm in management applications is the ...
Gavalas, Damianos
core   +1 more source

Main Map Value Preposition Design

open access: yes, 2021
Main Map Value Proposition Design. By : Monica Evelyn Tantienaffectio,NIM : 2401962900, Universitas Bina Nusantara. email : monica.tantienaffectio@binus.ac.id).Konten (canvas, design, test, & evolve). Refrence : (Alexander Osterwalder, Yves Pigneur, Greg Bernarda & Alan Smith (2014) Value Proposition Design, John Wiley & Sons ...
openaire   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Student Mathematics Performance in Year One Implementation of Teach to One: Math [PDF]

open access: yes, 2013
This report examines mathematics test data from the first year of implementation (2012-13) of the Teach to One: Math (TtO) approach in seven urban middle schools in Chicago, New York City, and Washington D.C.
Caron Mineo   +4 more
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

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