Results 111 to 120 of about 1,358,257 (368)

The Research Space: using the career paths of scholars to predict the evolution of the research output of individuals, institutions, and nations

, 2016
In recent years scholars have built maps of science by connecting the academic fields that cite each other, are cited together, or that cite a similar literature.
Aristarán, Manuel, Guevara, Miguel R., Hartmann, Dominik, Hidalgo, César A., Mendoza, Marcelo   +4 more
core   +1 more source

Prevention and screening during the COVID-19 pandemic: qualitative findings from the BETTER WISE project

BMC Primary Care, 2023
Background The COVID-19 pandemic challenged healthcare systems worldwide and disrupted primary care, particularly prevention, screening, and lifestyle counselling.
N. Sopcak, M. Wong, C. Fernandes, D. Ofosu, I. Khalil, D. Manca   +5 more
doaj   +1 more source

CFTR Lifecycle Map—A Systems Medicine Model of CFTR Maturation to Predict Possible Active Compound Combinations [PDF]

, 2021
Liza Vinhoven, Frauke Stanke, Sylvia Hafkemeyer, Manuel Nietert   +3 more
openalex   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Multicriteria VMAT optimization

, 2011
Purpose: To make the planning of volumetric modulated arc therapy (VMAT) faster and to explore the tradeoffs between planning objectives and delivery efficiency. Methods: A convex multicriteria dose optimization problem is solved for an angular grid of
Bedford, Bortfeld, Bzdusek, Carol, Chen, Craft, Craft, Craft, Craft, David Craft, Deasy, Dualta McQuaid, Ehsan Salari, Herman, Hong, Jelen, Jeremiah Wala, Luan, Men, Monz, Oliver, Otto, Rao, Rennen, Romeijn, Salter, Scherrer, Spirou, Stein, Svensson, Thieke, Thomas Bortfeld, Wang, Wei Chen, Woudstra, Yu, Yu, Zhang   +37 more
core   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Quantifying the Tibiofemoral Joint Space Using X-ray Tomosynthesis [PDF]

, 2011
Purpose: Digital x-ray tomosynthesis (DTS) has the potential to provide 3D information about the knee joint in a load-bearing posture, which may improve diagnosis and monitoring of knee osteoarthritis compared with projection radiography, the current ...
Heckel, Beth, Kalinosky, Benjamin, Piacsek, Kelly, Sabol, John M., Schmidt, Taly Gilat   +4 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Bias in machine learning applications to address non-communicable diseases at a population-level: a scoping review

BMC Public Health
Background Machine learning (ML) is increasingly used in population and public health to support epidemiological studies, surveillance, and evaluation.
Sharon Birdi, Roxana Rabet, Steve Durant, Atushi Patel, Tina Vosoughi, Mahek Shergill, Christy Costanian, Carolyn P. Ziegler, Shehzad Ali, David Buckeridge, Marzyeh Ghassemi, Jennifer Gibson, Ava John-Baptiste, Jillian Macklin, Melissa McCradden, Kwame McKenzie, Sharmistha Mishra, Parisa Naraei, Akwasi Owusu-Bempah, Laura Rosella, James Shaw, Ross Upshur, Andrew D. Pinto   +22 more
doaj   +1 more source