Results 131 to 140 of about 632,968 (345)

Functional annotation map of natural compounds in traditional Chinese medicines library: TCMs with myocardial protection as a case

, 2023
Xudong Xing, Mengru Sun, Zifan Guo, Yongjuan Zhao, Yu-Ru Cai, Ping Zhou, Huiying Wang, Wen Gao, Ping Li, Hua Yang   +9 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Guidelines and recommendations about virtual mental health services from high-income countries: a rapid review

BMJ Open
Objectives This study reviewed existing recommendations for virtual mental healthcare services through the quadruple aim framework to create a set of recommendations on virtual healthcare delivery to guide the development of Canadian policies on virtual ...
Monika Kastner, Helen Atherton, Martina Kelly, Peter Selby, Abban Yusuf, Elizabeth Anderson, Carolyn Ziegler, Braden O'Neill, Saadia Sediqzadah, Lucie Langford, Stephanie Montesanti, Ngozichukwuka Ekeleme, Karen Waite, Ginetta Salvalaggio, Tamara Do Amaral, Osnat C Melamed   +15 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Probe into research structure and development ideas of modernization of traditional Chinese medicine

Huli yanjiu, 2017
Objective:To study the development trend of traditional Chinese medicine modernization，and expand the space for the development of traditional Chinese medicine science.Methods:In this paper，the author used the endnote X7 to sort out the scientific ...
Luo Mingwei, Zhang Jian
doaj  

Developing patient-reported experience measures to evaluate an Emergency Department Outreach Programme for people experiencing homelessness in Toronto, Canada: a community-based participatory research study protocol

BMJ Open
Introduction People experiencing homelessness (PEH) have diverse and complex health and social needs and experience significant barriers to accessing support.
Curtis Handford, Andrew Pinto, Carolyn Snider, Sarah Xiao   +3 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Pediatric formulations in national essential medicines lists: a cross-sectional study

Frontiers in Pediatrics
BackgroundChildren need specialized medicine formulations for proper dosing, safety, and adherence. The World Health Organization developed a pediatric essential medicines list prioritising pediatric formulations.
Camila Heredia, Moizza Zia Ul Haq, Bernadette Cappello, Farihah Malik, Martina Penazzato, Lorenzo Moja, Navindra Persaud, Navindra Persaud   +7 more
doaj   +1 more source

Is ctDNA the Road Map to the Landscape of the Clonal Mutational Evolution in Drug Resistance? Lessons from the PALOMA-3 Study and Implications for Precision Medicine

, 2018
Rachel Schiff, Rinath Jeselsohn
openalex   +2 more sources