Results 131 to 140 of about 1,358,257 (368)

“We don't have a good system for people who don't have a home and don't need a hospital”: Contextualizing the hospital discharge process for people experiencing homelessness in Toronto, Canada

open access: yesSSM: Qualitative Research in Health, 2022
Hospital discharge is a key transition in a patient's care pathway, providing an effective point of intervention to address a patient's ongoing health and social care needs. Addressing these needs may prevent hospital readmissions. The hospital discharge
Jesse I.R. Jenkinson   +3 more
doaj  

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

open access: yesFEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li   +3 more
wiley   +1 more source

Developing priorities to achieve health equity through diabetes translation research: A concept mapping study [PDF]

open access: yes, 2019
Introduction: The goal of diabetes translation research is to advance research into practice and ensure equitable benefit from scientific evidence. This study uses concept mapping to inform and refine future directions of diabetes translation research ...
Haire-Joshu, Debra   +4 more
core   +1 more source

Interventions in ambulatory healthcare settings to reduce social isolation among adults aged 18–64: a systematic review

open access: yesBJGP Open
Background: Social isolation is associated with increased all-cause and premature mortality, poor chronic disease management, and mental health concerns.
Kavya Anchuri   +11 more
doaj   +1 more source

Economic barriers, evidentiary gaps, and ethical conundrums: a qualitative study of physicians’ challenges recommending HPV vaccination to older gay, bisexual, and other men who have sex with men

open access: yesInternational Journal for Equity in Health, 2019
Background The human papillomavirus (HPV) is the most common sexually transmitted infection (STI) worldwide. Gay, bisexual, and other men who have sex with men (GBM), and GBM living with HIV in particular, are disproportionately impacted by HPV ...
Daniel Grace   +6 more
doaj   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

open access: yesFEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász   +6 more
wiley   +1 more source

Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase

open access: yesFEBS Letters, EarlyView.
The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu   +5 more
wiley   +1 more source

Knowledge, understanding and the dynamics of medical innovation [PDF]

open access: yes
This paper investigates the processes by which scientific knowledge is created and legitimized. It focuses on scientific developments in a branch of medicine and explores the pathways through which the growth of knowledge enables advances in medical ...
Consoli, Davide, Ramlogan, Ronnie
core   +1 more source

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