Results 81 to 90 of about 1,443,694 (284)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Barriers and facilitators to safer supply pilot program implementation in Canada: a qualitative assessment of service provider perspectives

Harm Reduction Journal
Background In response to the ongoing drug toxicity crisis, driven by fentanyl and its analogues in the unregulated drug supply, Canada has funded several safer supply programs, which provide pharmaceutical-grade medications to reduce the reliance on ...
Frishta Nafeh, Lucas Martignetti, Carol Strike, Gillian Kolla, Matthew Bonn, Caroline Brunelle, Jade Boyd, Elaine Hyshka, Cassidy Morris, Jolene Eeuwes, Heather Hobbs, Elizabeth Haywood, Bernadette Pauly, Dan Werb, Mohammad Karamouzian   +14 more
doaj   +1 more source

Validation of a standardised approach to collect sociodemographic and social needs data in Canadian primary care: cross-sectional study of the SPARK tool

BMJ Open
Objective This study validates the previously tested Screening for Poverty And Related social determinants to improve Knowledge of and access to resources (‘SPARK Tool’) against comparison questions from well-established national surveys (Post Survey ...
Kris Aubrey-Bassler, Alan Katz, Emily Gard Marshall, Itunuoluwa Adekoya, Nazeem Muhajarine, Andrew David Pinto, Alannah Delahunty-Pike, Dana Howse, Leanne Kosowan, Abigail Zita Seshie, Eunice Abaga, Jane Cooney, Marjeiry Robinson, Dorothy Senior, Alexander Zsager, Joseph J O’Rourke, Cory Neudorf, Mandi Irwin   +17 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Hospital and Physician Capacity Update [PDF]

, 2009
Offers an alternative view of healthcare costs by examining trends in hospital capacity and healthcare labor across regions. Outlines how effective management of healthcare capacity would enable affordable quality care that meets patient needs and ...
David C. Goodman, Elliott S. Fisher, Kristen K. Bronner   +2 more
core  

A world map of evidence-based medicine: Density equalizing mapping of the Cochrane database of systematic reviews

PLOS ONE, 2019
Systematic reviews represent the core and backbone of evidence-based medicine (EBM) strategies in all fields of medicine. In order to depict a first global sketch of the international efforts in the Cochrane database systematic reviews (CDSR), we analyzed the systematic reviews of the Cochrane database.
David A. Groneberg, Stefan Rolle, Michael H. K. Bendels, Doris Klingelhöfer, Norman Schöffel, Jan Bauer, Dörthe Brüggmann   +6 more
openaire   +6 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Primary care provider and clinic staff perspectives on the collection of demographic and social needs data in primary care clinics across five Canadian provinces

Family Medicine and Community Health
Objective This study reports on the barriers and facilitators experienced by primary care providers, clinic staff and clinic leadership when implementing the SPARK Tool to collect demographic and social needs data in primary care clinics across Canada ...
Kris Aubrey-Bassler, Emily Gard Marshall, Itunuoluwa Adekoya, Nazeem Muhajarine, Archna Gupta, Mélanie Ann Smithman, Alannah Delahunty-Pike, Dana Howse, Leanne Kosowan, Abigail Zita Seshie, Eunice Abaga, Marjeiry Robinson, Alexander Zsager, Cory Neudorf, Joseph J. O’Rourke, Lane Williams, Isabelle Fortuna, Andrew D. Pinto   +17 more
doaj   +1 more source